先天性淋巴细胞
生物
细胞代谢
免疫
疾病
生物能学
炎症
细胞生物学
获得性免疫系统
免疫学
先天免疫系统
细胞因子
细胞
免疫系统
线粒体
医学
遗传学
病理
作者
Lei Zhou,Qingxia Lin,Gregory F. Sonnenberg
标识
DOI:10.1038/s42255-022-00685-8
摘要
Innate lymphoid cells (ILCs) are a family of predominantly tissue-resident lymphocytes that critically orchestrate immunity, inflammation, tolerance and repair at barrier surfaces of the mammalian body. Heterogeneity among ILC subsets is comparable to that of adaptive CD4+ T helper cell counterparts, and emerging studies demonstrate that ILC biology is also dictated by cellular metabolism that adapts bioenergetic requirements during activation, proliferation or cytokine production. Accumulating evidence in mouse models and human samples indicates that ILCs exhibit profound roles in shaping states of metabolic health and disease. Here we summarize and discuss our current knowledge of the cell-intrinsic and cell-extrinsic metabolic factors controlling ILC responses, as well as highlight contributions of ILCs to organismal metabolism. It is expected that continued research in this area will advance our understanding of how to manipulate ILCs or their metabolism for therapeutic strategies that benefit human health.
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