雷尼镍业
堵塞
流动化学
镍
连续流动
化学
停留时间(流体动力学)
体积热力学
催化作用
工艺工程
环境科学
废物管理
化学工程
有机化学
工程类
物理
岩土工程
考古
量子力学
生化工程
历史
作者
Hahyeon Kim,Jonghyun Lee,Seung‐Jae Lee,Jeong Eun Oh,Soo Dong Kim,Yashwardhan R. Malpani,Ye‐Jin Hwang,Boyoung Y. Park
标识
DOI:10.1016/j.jiec.2022.11.052
摘要
A clog-free sustainable method for the synthesis of ursodeoxycholic acid through selective hydrogenation was developed using Raney nickel in a continuous flow process. To increase the sustainability and safety of the continuous flow system, water as a green solvent was used to remove the salt compound causing serious clogging problems and to generate hydrogen gas by electrolysis. Furthermore, a real-time monitoring system was installed in the flow system to check the system pressure and collective volume of the reaction solution, allowing immediate confirmation of blockages. Eventually, the continuous flow system was successfully developed with a short residence time of 4 min, almost full conversion, and high selectivity of 94.0% dr. This continuous flow system lasts 10 consecutive days with lower catalyst loading (the ratio of Raney nickel to 7-oxo-LCA = 4.44 w/w) without clogging problems.
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