药品
临床试验
疾病
癌症研究
医学
药理学
作用机理
机制（生物学）
生物
内科学
遗传学
体外
哲学
认识论
出处
期刊：Cancer Discovery
[American Association for Cancer Research]
日期：2023-01-09
卷期号：13 (1): 4-4
标识
DOI：10.1158/2159-8290.cd-nb2022-0067
摘要
The first direct inhibitor of MYC to enter human clinical testing appears to be safe, with signs of antitumor activity in patients with advanced solid cancers. Treatment with OMO-103 led to stable disease in about half of trial participants, but the drug's mechanism of action and the extent of on-target engagement remain matters of debate.
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