自愈水凝胶
木质素
明胶
肿胀 的
差示扫描量热法
化学工程
材料科学
膨胀能力
傅里叶变换红外光谱
化学
高分子化学
核化学
有机化学
复合材料
物理
工程类
热力学
作者
Elahe Chiani,Anne Beaucamp,Yahya Hamzeh,Mohammad Azadfallah,A. V. Thanusha,Maurice N. Collins
标识
DOI:10.1016/j.ijbiomac.2022.10.205
摘要
In this study, hydrogels based on gelatin and lignin were fabricated as efficient drug carriers for Ribavirin. The obtained hydrogels were characterized by scanning electron microscopy (SEM), ATR-FTIR spectroscopy, differential scanning calorimetry (DSC), mechanical compression and rheometry. Results showed that the pore structure, viscoelastic behavior and swelling ability significantly influenced by varying lignin content and crosslinker ratio. By increasing the crosslinker N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) content, the pore size became smaller, while increasing the lignin content resulted in larger pores. In addition, all hydrogels show strong shear thinning behavior. Ribavirin was used as a drug model, and its release rate was enhanced by increasing lignin content in the binary hydrogel structure. A higher Ribavirin cumulative release was observed for gelatin/lignin with higher lignin content (3 %) hydrogel. These findings emphasize the chemical composition on the structure and the release behavior of lignin-containing hydrogels.
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