Distribution network is an urban infrastructure, which is of great significance to the safety of urban power supply. Self-healing control is an effective means to solve the safe operation of distribution network and has become a hot research topic in the field of distribution. Combining DSSR and TSC theory with self-healing control system, this paper proposes a safe and efficient operation mode of distribution network based on security domain. The self-healing control system based on security domain is presented, the preventive control, predictive control and optimization control based on DSSR and TSC are proposed, and these functions are demonstrated by an example of a real distribution network. Self-healing control emphasizes initiative, and the safety domain theory gives the direction and measurement of load control. Preventive control or predictive control is adopted to ensure the operation of the power grid in the safety domain, so as to ensure the safety and reliability of power supply can be improved greatly.