活性氧
酶
过氧化物酶
纳米片
化学
谷胱甘肽
抗氧化剂
谷胱甘肽过氧化物酶
纳米技术
生物物理学
材料科学
组合化学
生物化学
生物
作者
Xinqiang Liang,Yanping Tang,Mekhrdod Subhoni,Danni Luo,Guangzhong Tu,Pengle Xia,Shufang Ning,Litu Zhang,Chen Wang
标识
DOI:10.3389/fphar.2023.1324764
摘要
The clinical application of reactive oxygen species (ROS)-mediated tumor treatment has been critically limited by inefficient ROS generation. Herein, we rationally synthesized and constructed the three-dimensional PdMo nanoflowers through a one-pot solvothermal reduction method for elaborately regulated peroxidase-like enzymatic activity and glutathione peroxidase-like enzymatic activity, to promote oxidation ROS evolvement and antioxidation glutathione depletion for achieving intensive ROS-mediated tumor therapy. The three-dimensional superstructure composed of two-dimensional nanosheet subunits can solve the issues by avoiding the appearance of tightly stacked crystalline nanostructures. Significantly, Mo is chosen as a second metal to alloy with Pd because of its more chemical valence and negative ionization energy than Pd for improved electron transfer efficiencies and enhanced enzyme-like activities. In addition, the photothermal effect generated by PdMo nanoflowers could also enhance its enzymatic activities. Thus, this work provides a promising paradigm for achieving highly ROS-mediated tumor therapeutic efficacy by regulating the multi-enzymatic activities of Pd-based nanoalloys.
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