Neutrophils/Lymphocytes Ratio and Platelets/Lymphocytes Ratio and Its Relationship with Severity and Functional Prognosis in Patients with Acute Ischemic Stroke (P5.235)

BACKGROUND AND OBJECTIVE Neutrophils/lymphocytes (N/L) ratio and platelets/lymphocytes (P/L) ratio are considered important inflammatory markers and potential predictors of cardiovascular risk. It has been shown that the N/L ratio in patients with ischemic stroke is greater than in patients with transient ischemic attack and healthy patients. Our aim was to study the existing correlation between the N/L ratio and P/L ratio at hospital admission with severity and functional prognosis in patients with acute ischemic stroke. METHODS It was a prospective longitudinal study, in which 48 male and 40 female patients between 50 and 95 years diagnosed with Acute Ischemic Stroke. We excluded patients admitted with more than 48 hours of evolution, those documented with infection 72 hours before or after admission, patients with active cancer, rheumatologic, liver and endocrine diseases or patients who received systemic corticosteroids. The severity and functional outcome variables were quantified by the NIHSS and modified Rankin scales respectively. RESULTS A positive correlation between NIHSS and N/L ratio, NIHSS and P/L ratio, was observed both in men and women (r = 0.53, p <0.0001 and r = 0.58, p <0.0001) (r = 0.32, p = 0.02 r = 0.44, p = 0.004) respectively. Also, the functional prognosis showed a positive correlation with N/L ratio and P/L ratio both in men and women (r = 0.47, p = 0.0007 and r = 0.56, p = 0.0001) (r = 0.31, p = 0.02 and r = 0.53, p = 0.0004) respectively. CONCLUSIONS N/L ratio and P/L ratio at hospital admission have a positive correlation with the severity and functional prognosis of patients with Acute Ischemic Stroke. Due to its simple determination, affordable and safe, they could become severity and functional prognostic parameters in the initial evaluation of patients with Acute Ischemic Stroke in the future.