化学
对映选择合成
联苯
组合化学
产量(工程)
配体(生物化学)
钯
铃木反应
催化作用
侧链
有机化学
受体
生物化学
冶金
材料科学
聚合物
作者
Hong-Yu Qu,Wen‐Hua Zheng
标识
DOI:10.1021/acs.orglett.3c03487
摘要
Herein, we describe our design and synthesis of novel chiral monophosphine ligands by the short-step addition of chiral lactates as side chains to the well-known ligand SPhos/RuPhos. The new chiral ligands were shown to be highly efficient in palladium-catalyzed Suzuki-Miyaura coupling, providing a series of axially chiral biphenyl products in high yield and high enantioselectivity. Furthermore, the gram-scale reaction and the diverse conversions of the products demonstrated the potential utility of the approach.
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