生物
CD8型
主要组织相容性复合体
时间轴
细胞毒性T细胞
转录因子
T细胞
T细胞受体
转录组
谱系(遗传)
否定选择
计算生物学
遗传学
基因表达
抗原
基因
免疫系统
基因组
历史
考古
体外
作者
Zoë Steier,Esther Jeong Yoon Kim,Dominik A. Aylard,Ellen A. Robey
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2024-06-28
卷期号:42 (1): 235-258
被引量:4
标识
DOI:10.1146/annurev-immunol-083122-040929
摘要
The choice of developing thymocytes to become CD8 + cytotoxic or CD4 + helper T cells has been intensely studied, but many of the underlying mechanisms remain to be elucidated. Recent multiomics approaches have provided much higher resolution analysis of gene expression in developing thymocytes than was previously achievable, thereby offering a fresh perspective on this question. Focusing on our recent studies using CITE-seq (cellular indexing of transcriptomes and epitopes) analyses of mouse thymocytes, we present a detailed timeline of RNA and protein expression changes during CD8 versus CD4 T cell differentiation. We also revisit our current understanding of the links between T cell receptor signaling and expression of the lineage-defining transcription factors ThPOK and RUNX3. Finally, we propose a sequential selection model to explain the tight linkage between MHC-I versus MHC-II recognition and T cell lineage choice. This model incorporates key aspects of previously proposed kinetic signaling, instructive, and stochastic/selection models.
科研通智能强力驱动
Strongly Powered by AbleSci AI