表观遗传学
表观遗传疗法
组蛋白
DNA甲基化
癌症表观遗传学
生物
癌症
癌症研究
组蛋白脱乙酰基酶
表观遗传学
乙酰化
生物信息学
计算生物学
遗传学
基因表达
基因
组蛋白甲基转移酶
作者
Lei Tao,Yue Zhou,Yuan Luo,Jiahao Qiu,Yuzhou Xiao,Jiao Zou,Yu Zhang,Xingchen Liu,Xinyu Yang,Kun Gou,Jing Xu,Xinqi Guan,Xiaobo Cen,Yinglan Zhao
摘要
Abstract Epigenetic regulation refers to the alteration of gene expression independent of changes in DNA sequence. It involves chemical modifications such as DNA methylation, histone methylation, and histone acetylation, which are regulated by a coordinated interplay of various regulators to ensure precise spatial and temporal regulation of gene expression. Epigenetic aberrations are commonly observed in cancer and are considered as hallmarks of cancer. In recent years, small molecules targeting specific epigenetic regulators have been developed and are demonstrating promising therapeutic potential in preclinical and clinical trials for cancer treatment. In this review, we summarize the essential regulatory mechanisms and dysfunctions of epigenetic regulators involved in DNA methylation, histone methylation, and histone acetylation during tumor development and progression. Moreover, we discuss the current advances and challenges in cancer epigenetic therapy that target these mechanisms in both hematologic malignancies and solid tumors. Finally, we discuss the potential of combining epigenetic drugs with other therapies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, as a promising approach for cancer treatment. Overall, we aim to enhance the understanding of epigenetic regulation in cancer therapy and explore targeted therapeutic strategies based on these mechanisms, to ultimately advance cancer therapy and improve patient prognosis.
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