A biomimetic lubricating nanosystem for synergistic therapy of osteoarthritis

骨关节炎 纳米技术 化学 医学 材料科学 替代医学 病理
作者
Peiwei Gong,Meng Wang,Jiangli Wang,Junyao Li,Bairen Wang,Xiao Bai,Jianxi Liu,Zhe Liu,Dandan Wang,Weimin Liu
出处
期刊:Journal of Colloid and Interface Science [Elsevier BV]
卷期号:672: 589-599 被引量:7
标识
DOI:10.1016/j.jcis.2024.06.009
摘要

Failure of articular cartilage lubrication and inflammation are the main causes of osteoarthritis (OA), and integrated treatment realizing joint lubrication and anti-inflammation is becoming the most effective treat model. Inspired by low friction of human synovial fluid and adhesive chemical effect of mussels, our work reports a biomimetic lubricating system that realizes long-time lubrication, photothermal responsiveness and anti-inflammation property. To build the system, a dopamine-mediated strategy is developed to controllably graft hyaluronic acid on the surface of metal organic framework. The design constructs a biomimetic core–shell structure that has good dispersity and stability in water with a high drug loading ratio of 99%. Temperature of the solution rapidly increases to 55 °C under near-infrared light, and the hard-soft lubricating system well adheres to wear surfaces, and greatly reduces frictional coefficient by 75% for more than 7200 times without failure. Cell experiments show that the nanosystem enters cells by endocytosis, and releases medication in a sustained manner. The anti-inflammatory outcomes validate that the nanosystem prevents the progression of OA by down-regulating catabolic proteases and pain-related genes and up-regulating genes that are anabolic in cartilage. The study provides a bioinspired strategy to employ metal organic framework with controlled surface and structure for friction reduction and anti-inflammation, and develops a new concept of OA synergistic therapy model for practical applications.
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