医学
危险系数
内科学
移植
累积发病率
肿瘤科
髓样
造血干细胞移植
入射(几何)
造血
多元分析
干细胞
髓性白血病
胃肠病学
置信区间
生物
遗传学
物理
光学
作者
Carlos Jiménez‐Vicente,Paola Charry,Sandra Castaño‐Díez,Francesca Guijarro,Mònica López‐Guerra,Amanda Isabel Pérez‐Valencia,Alexandra Martínez‐Roca,Albert Cortés‐Bullich,Daniel Munárriz,María Teresa Solano,Laura Rosiñol,Enric Carreras,Álvaro Urbano-Ispízua,Françesc Fernández-Avilés,Carmen Martı́nez,María Suárez‐Lledó,Marina Díaz‐Beyá,Montserrat Rovira,María Queralt Salas,Jordi Esteve
摘要
Summary European LeukemiaNet refined their risk classification of acute myeloid leukaemia (AML) in 2022 (ELN 2022) according to the two new myeloid classifications published the same year. We have retrospectively assessed the prognostic value of the ELN 2022 in 120 AML patients undergoing allogeneic haematopoietic cell transplantation (allo‐HCT), including 99 in first complete response (CR1) from 2011 to 2021 in our centre. Adverse risk patients (Adv) presented inferior outcome in terms of overall survival (OS) and leukaemia‐free survival (LFS) (OS [ p = 0.003], LFS [ p = 0.02]), confirmed in multivariate analysis (hazard ratio [HR] for OS = 2.00, p = 0.037). These results were also seen in patients allografted in CR1. Further analysis identified a subgroup named adverse‐plus (AdvP), including complex karyotype, MECOM(EVI1) rearrangements and TP53 mutations, with worse outcomes than the rest of groups of patients, including the Adv (HR for OS: 3.14, p < 0.001, HR for LFS: 3.36, p < 0.001), with higher 2‐year cumulative incidence of relapse ( p < 0.001). Notably, within this analysis, the outcome of Adv and intermediate patients were similar. These findings highlight the prognostic value of ELN 2022 in patients undergoing allo‐HCT, which can be improved by the recognition of a poor genetic subset (AdvP) within the Adv risk group.
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