Abstract Nitrogen oxides (NOx) are produced during the high‐temperature combustion process of fossil fuels, which are considered as an atmospheric pollutant that can lead to significant environmental issues such as acid rain and photochemical smog. Therefore, it is essential to minimize the concentration of NO x in the atmosphere in order to protect the ecological environment upon which human beings depends. The integrated utilization of NO x removal technology results in environmentally harmless compounds, such as N 2 and H 2 O, through the processes like adsorption, separation, catalytic reduction and other methods. Metal‐organic frameworks (MOFs) are seen as ideal candidates for addressing NO x pollution issues in the atmosphere due to their high specific surface area, ultrahigh porosity and unlimited modifiability. Herein, the latest research progress in MOFs and MOFs‐derived materials related to NO x adsorption, separation and catalytic reduction is presented and summarized. Besides, some opportunities and problems need to be solved in this field are proposed and discussed.