Tuning multiple enzyme-like activities by metal doping for identification and quantitation of antioxidants in cosmetics

化妆品 化学 鉴定(生物学) 色谱法 金属 组合化学 生物化学 有机化学 生物 植物
作者
Sheng-Tao Wu,Hui-Qi Su,Kai-Lin Shen,Ying Li,Yi Ge,Xiu-Fang Cheng,Changming Nie,Conghui Wang,Ying‐Wu Lin
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:491: 152120-152120 被引量:1
标识
DOI:10.1016/j.cej.2024.152120
摘要

Inspired by the hydrolysis behaviors of skin cells, we exquisitely designed and synthesized a class of hydrolase mimics to develop an analytical method that can both identify and quantity antioxidant components in skin-whitening cosmetics, including ascorbic acid (AA) and its glycoside and phosphate derivatives. A series of ultra-thin Cu1-xMnxO2 or Fe1-yMnyO2 with rich acid-base pairs were prepared via chemical deposition and in-situ CuI/FeII self-assembly. H218O and D216O isotopic labeling studies and density function theory (DFT) calculations were adopted to analyze the cleaving sites of ascorbyl phosphate (AAL)/ascorbyl glucoside (AAP) and confirm that H2O was involved in the new bonds. In-situ DRIFT NH3-IR and −TPD further confirmed that the Fe- or Cu-substitution could increase the quantity and strength of Brønsted and Lewis acid sites. A cascade catalytic fluorescence sensor was designed for selective recognition or quantification of AA and its derivatives, which presents ultra-high-precision (≤2.5 %), stability, and selectivity in testing the target ingredients of five cosmetics from the market. Our nanozymes exhibit higher catalytic efficiency of 17.1 s−1 for AA, 8.42 s−1 for AAL, and 3.32 s−1 for AAP, which are 5.6 ∼ 32.8-fold higher than those of their mimic proteases. This work provides a controllable methodology to design hydrolytic nanozymes, which sheds light on biomimetic engineering and paves the way for breakthroughs in cosmetics industrial applications in the future.
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