A review of natural astaxanthin production in a circular bioeconomy context using Paracoccus carotinifaciens

Astaxanthin (AXT) is a ketocarotenoid with several properties, including antioxidant, antidiabetic and anticancer with a wide range of applications in cosmeceutical, feed, food and pharmaceuticals sectors. The large fraction of AXT available in the market is obtained by chemical route, but the consumers preference for natural products are changing the global market of AXT, and due to that several companies are looking for potential alternative sources such as Gram-negative bacteria Paracoccus carotinifaciens (P. carotinifaciens) to obtain natural AXT. The aim of this critical review is to provide a comprehensive overview of the latest AXT research findings and characteristics of the hyperproducer-AXT P. carotinifaciens. Moreover, a brief description of the potential application of P. carotinifaciens for the production of natural AXT at industrial scale for commercial purposes and the latest advancements in the upstream and downstream procedures following the biorefinery and circular economy percepts are considered.