骨桥蛋白
CD14型
内科学
医学
免疫学
心力衰竭
纤维化
人口
趋化因子
免疫系统
内分泌学
环境卫生
作者
Jake A Robinson,Mabel Toribio,Thiago Quinaglia,Magid Awadalla,Ria Talathi,Claudia G Durbin,Iad Alhallak,David A Alagpulinsa,Lindsay T Fourman,Giselle Alexandra Suero-Abreu,Michael D Nelson,Takara L Stanley,Christopher T Longenecker,Lidia S Szczepaniak,Michael Jerosch-Herold,Tomas G Neilan,Markella V Zanni,Tricia H Burdo
出处
期刊:AIDS
[Ovid Technologies (Wolters Kluwer)]
日期:2022-11-03
卷期号:37 (2): 305-310
被引量:1
标识
DOI:10.1097/qad.0000000000003417
摘要
Women with HIV (WWH) have heightened heart failure risk. Plasma OPN (osteopontin) is a powerful predictor of heart failure outcomes in the general population. Limited data exist on relationships between plasma OPN and surrogates of HIV-associated heart failure risk.Prospective, cross-sectional.We analyzed relationships between plasma OPN and cardiac structure/function (assessed using cardiovascular magnetic resonance imaging) and immune activation (biomarkers and flow cytometry) among 20 WWH and 14 women without HIV (WWOH).Plasma OPN did not differ between groups. Among WWH, plasma OPN related directly to the markers of cardiac fibrosis, growth differentiation factor-15 (ρ = 0.51, P = 0.02) and soluble interleukin 1 receptor-like 1 (ρ = 0.45, P = 0.0459). Among WWH (but not among WWOH or the whole group), plasma OPN related directly to both myocardial fibrosis (ρ = 0.49, P = 0.03) and myocardial steatosis (ρ = 0.46, P = 0.0487). Among the whole group and WWH (and not among WWOH), plasma OPN related directly to the surface expression of C-X3-C motif chemokine receptor 1 (CX3CR1) on nonclassical (CD14-CD16+) monocytes (whole group: ρ = 0.36, P = 0.04; WWH: ρ = 0.46, P = 0.04). Further, among WWH and WWOH (and not among the whole group), plasma OPN related directly to the surface expression of CC motif chemokine receptor 2 (CCR2) on inflammatory (CD14+CD16+) monocytes (WWH: ρ = 0.54, P = 0.01; WWOH: ρ = 0.60, P = 0.03), and in WWH, this held even after controlling for HIV-specific parameters.Among WWH, plasma OPN, a powerful predictor of heart failure outcomes, related to myocardial fibrosis and steatosis and the expression of CCR2 and CX3CR1 on select monocyte subpopulations. OPN may play a role in heart failure pathogenesis among WWH.NCT02874703.
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