白癜风
托法替尼
黑素细胞
表皮(动物学)
真皮
化学
角质层
材料科学
医学
皮肤病科
免疫学
癌症研究
病理
黑色素瘤
解剖
类风湿性关节炎
作者
Jingyao Liang,Yihui Yu,Changxing Li,Qian Li,Pingjiao Chen,Wěi Li,Wenyan Liu,Zhenjie Li,Yu Liu,Sanquan Zhang,Xibao Zhang
标识
DOI:10.1016/j.carbpol.2023.120549
摘要
Vitiligo can cause serious damage to the appearance of patients and affect physical and mental health, but there is currently no simple and effective treatment. According to the theory of autoimmune disorder, the separable hydrogel microneedles delivering alpha-melanocyte-stimulating hormone (α-MSH) and tofacitinib were designed to treat vitiligo. This hydrogel microneedles were formed by dextran methacrylate (DexMA) and cyclodextrin-adamantane based host-guest supramolecules (HGSM) through CC double bond polymerization and host-guest assembly. The microneedle tips formed by the double cross-linked hydrogel can pierce the stratum corneum and deliver melanocyte protector α-MSH and JAK inhibitor tofacitinib directly to the epidermis and dermis. Under the treatment of α-MSH/tofacitinib microneedles, massive deposition of melanin in epidermis and hair follicles significantly accelerated skin and hair pigmentation.
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