Tumor microenvironment responsiveT1–T2dual-mode contrast agent Fe3O4@ZIF-8-Zn–Mn NPs forin vivomagnetic resonance imaging

A pH and glutathione sensitive assembly Fe 3 O 4 @ZIF-8-Zn-Mn was constructed via one step self-assembly in aqueous solution. This assembly can be used as tumor microenvironment responsive T 1 – T 2 dual-mode magnetic resonance imaging contrast agent for tumor imaging.