Rebalancing Cardiac Structure and Function With Synthetic Mitochondria-Endoplasmic Reticulum Tethers

HomeCirculation ResearchVol. 132, No. 11Rebalancing Cardiac Structure and Function With Synthetic Mitochondria-Endoplasmic Reticulum Tethers No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextRebalancing Cardiac Structure and Function With Synthetic Mitochondria-Endoplasmic Reticulum Tethers Prasanna Katti and Brian Glancy Prasanna KattiPrasanna Katti https://orcid.org/0000-0002-6748-3460 National Heart, Lung, and Blood Institute (P.K., B.G.), National Institutes of Health, Bethesda, MD. Search for more papers by this author and Brian GlancyBrian Glancy Correspondence to: Brian Glancy, PhD, National Institutes of Health, 10 Center Dr, Room B1D416, Bethesda, MD 20892. Email E-mail Address: [email protected] https://orcid.org/0000-0002-8571-244X National Heart, Lung, and Blood Institute (P.K., B.G.), National Institutes of Health, Bethesda, MD. National Institute of Arthritis and Musculoskeletal and Skin Diseases (B.G.), National Institutes of Health, Bethesda, MD. Search for more papers by this author Originally published25 May 2023https://doi.org/10.1161/CIRCRESAHA.123.322911Circulation Research. 2023;132:1465–1467This article is a commentary on the followingEnhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle RemodelingFootnotesFor Sources of Funding and Disclosures, see page 1467.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Brian Glancy, PhD, National Institutes of Health, 10 Center Dr, Room B1D416, Bethesda, MD 20892. Email brian.glancy@nih.govReferences1. Lopez-Crisosto C, Pennanen C, Vasquez-Trincado C, Morales PE, Bravo-Sagua R, Quest AFG, Chiong M, Lavandero S. Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.Nat Rev Cardiol. 2017; 14:342–360. doi: 10.1038/nrcardio.2017.23CrossrefMedlineGoogle Scholar2. Csordas G, Weaver D, Hajnoczky G. Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions.Trends Cell Biol. 2018; 28:523–540. doi: 10.1016/j.tcb.2018.02.009CrossrefMedlineGoogle Scholar3. Glancy B, Kim Y, Katti P, Willingham TB. The functional impact of mitochondrial structure across subcellular scales.Front Physiol. 2020; 11:541040. doi: 10.3389/fphys.2020.541040CrossrefMedlineGoogle Scholar4. Lever J, Chappell J. Mitochondria isolated from rat brown adipose tissue and liver.J Cell Biol. 1958; 4:287–290. doi: 10.1083/jcb.4.3.287CrossrefGoogle Scholar5. Copeland D, Dalton A. An association between mitochondria and the endoplasmic reticulum in cells of the pseudobranch gland of a teleost.J Cell Biol. 1959; 5:393–396. doi: 10.1083/jcb.5.3.393CrossrefGoogle Scholar6. Csordas G, Renken C, Varnai P, Walter L, Weaver D, Buttle KF, Balla T, Mannella CA, Hajnoczky G. Structural and functional features and significance of the physical linkage between ER and mitochondria.J Cell Biol. 2006; 174:915–921. doi: 10.1083/jcb.200604016CrossrefMedlineGoogle Scholar7. Chandhok G, Lazarou M, Neumann B. Structure, function, and regulation of mitofusin-2 in health and disease.Biol Rev. 2018; 93:933–949. doi: 10.1111/brv.12378CrossrefMedlineGoogle Scholar8. Gordaliza-Alaguero I, Canto C, Zorzano A. Metabolic implications of organelle–mitochondria communication.EMBO Rep. 2019; 20:e47928. doi: 10.15252/embr.201947928CrossrefMedlineGoogle Scholar9. Kors S, Hacker C, Bolton C, Maier R, Reimann L, Kitchener EJ, Warscheid B, Costello JL, Schrader M. Regulating peroxisome–ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β.J Cell Biol. 2022; 221:e202003143. doi: 10.1083/jcb.202003143CrossrefMedlineGoogle Scholar10. Nichtová Z, Fernandez-Sanz C, De La Fuente S, Yuan Y, Hurst S, Lanvermann S, Tsai HY, Weaver D, Baggett A, Thompson C. Enhanced mitochondria-SR tethering triggers adaptive cardiac muscle remodeling.Circ Res. 2023; 132:e171–e187. doi: 10.1161/CIRCRESAHA.122.321833LinkGoogle Scholar11. Eisner DA, Caldwell JL, Kistamás K, Trafford AW. Calcium and excitation-contraction coupling in the heart.Circ Res. 2017; 121:181–195. doi: 10.1161/CIRCRESAHA.117.310230LinkGoogle Scholar12. Glancy B, Balaban RS. Role of mitochondrial Ca2+ in the regulation of cellular energetics.Biochemistry. 2012; 51:2959–2973. doi: 10.1021/bi2018909CrossrefMedlineGoogle Scholar13. McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism.Physiol Rev. 1990; 70:391–425. doi: 10.1152/physrev.1990.70.2.391CrossrefMedlineGoogle Scholar14. Eisner V, Picard M, Hajnoczky G. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.Nat Cell Biol. 2018; 20:755–765. doi: 10.1038/s41556-018-0133-0CrossrefMedlineGoogle Scholar15. Ren J, Bi Y, Sowers JR, Hetz C, Zhang Y. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases.Nat Rev Cardiol. 2021; 18:499–521. doi: 10.1038/s41569-021-00511-wCrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesEnhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle RemodelingZuzana Nichtová, et al. Circulation Research. 2023;132:e171-e187 May 26, 2023Vol 132, Issue 11 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.322911PMID: 37228240 Originally publishedMay 25, 2023 KeywordsEditorialattentionbiologyischemiareperfusionPDF download Advertisement