败血症
医学
微泡
重症监护医学
背景(考古学)
药品
细胞外小泡
外体
疾病
胞外囊泡
感染性休克
免疫学
内科学
药理学
生物
小RNA
生物化学
基因
古生物学
细胞生物学
作者
Roushka Bhagwan Valjee,Usri H. Ibrahim,Kwanele Xulu,Saajida Mahomed,Irene Mackraj
标识
DOI:10.1016/j.smaim.2023.06.007
摘要
Sepsis and sepsis-related organ dysfunction have been identified as significant global life-threatening health threats, with a high mortality rate despite ongoing research in the area. Timely diagnosis is essential such that treatment could be initiated as early as possible to ensure the best outcome, since delayed intervention is associated with a higher mortality. Patient stratification and disease monitoring, present significant challenges in sepsis treatment and management strategies, largely due to the heterogenicity of sepsis signs and symptoms. Hence a focus on potential biomarkers to overcome these challenges is needed. Recently, extracellular vesicles (EVs), mainly the exosome subtype, have been investigated regarding their potential role in sepsis diagnostics, therapeutics and as drug delivery vehicles. Herein, we present an up-to-date review covering the role of circulating exosomes in the diagnosis and monitoring of the progression of sepsis and in therapeutics and drug delivery for sepsis. To provide context, sepsis pathophysiology and the role of circulating exosomes in sepsis have been highlighted. Future prospects, current challenges and recommendations regarding the role of exosomes in sepsis are also identified.
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