背景(考古学)
癌变
病理
基底细胞癌
生物
免疫组织化学
基底细胞
医学
基因
遗传学
古生物学
作者
Thibault Kervarrec,Pierre Sohier,Daniel Pissaloux,Arnaud de la Fouchardière,B. Cribier,Maxime Battistella,Nicolas Macagno
标识
DOI:10.1016/j.annder.2023.03.003
摘要
Cutaneous adnexal tumors form a vast heterogeneous group that include frequent entities that are mostly benign, as well as rare tumors that are occasionally malignant. In contrast to cutaneous tumors arising from the interfollicular epidermis that develop as a result of accumulation of UV-induced DNA damage (basal cell carcinoma, squamous cell carcinoma), the oncogenesis of adnexal tumors is related to a broad spectrum of genetic mechanisms (e.g., point mutation, fusion genes, viral integration, etc.). In this setting, specific and recurrent genetic alterations have been progressively reported, and these allow better classification of these entities. For certain of them, immunohistochemical tools are now available, enabling precise integrated histological and molecular diagnosis since certain entities are linked to well-defined alterations. In this context, we aim in this review to summarize the main molecular tools currently available for the classification of adnexal tumors.
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