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Correlation of the surface expression of thymic stromal lymphopoietin receptor with the presence of CRLF2 gene rearrangements in children with B‐lineage acute lymphoblastic leukemia

流式细胞术 胸腺基质淋巴细胞生成素 免疫分型 医学 间质细胞 淋巴细胞白血病 队列 基因 相关性 癌症研究 分子生物学 受体 免疫学 白血病 内科学 生物 遗传学 数学 几何学
作者
I. A. Demina,Elena Zerkalenkova,Olga Soldatkina,Anna Kazakova,Alexandra Semchenkova,Maria Goncharova,Galina Novichkova,Michael Maschan,Alexander Karachunskiy,Yulia Olshanskaya,А. М. Попов
出处
期刊:International Journal of Laboratory Hematology [Wiley]
卷期号:45 (3): 337-343 被引量:1
标识
DOI:10.1111/ijlh.14028
摘要

In this study, we aimed to compare the immunophenotype of tumor cells in children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harboring rearrangements of the CRLF2 gene with that in children without such aberrations with a specific focus on the surface expression of the related protein thymic stromal lymphopoietin receptor (TSLPR).We examined bone marrow samples from 46 patients with primary BCP-ALL who had CRLF2 rearrangements detected by FISH (CRLF2(+) cohort). A total of 140 consecutive patients with intact CRLF2 were included in a control CRLF2(-) cohort. TSLPR expression was studied by flow cytometry.The majority of CRLF2(+) patients were conventionally positive (≥20% positive cells) for TSLPR (33 of 46, 71.7%). Among the remaining children in this group, two were completely TSLPR-negative, seven had less than 10% TSLPR-positive cells, and four had between 10% and 20% TSLPR-positive cells. By contrast, the majority of CRLF2(-) patients had no TSLPR-positive cells (119 of 140, 85.0%), while in 15 cases (10.7%), the percentage of TSLPR-positive cells was below 10%, and in six cases (4.3%), it was between 10% and 20%. Receiver operator characteristic analysis revealed a threshold of only 1.6% TSLPR-positive cells for the effective prediction of the presence of CRLF2 rearrangement. Moreover, this threshold retained its predictive value when only children with low TSLPR positivity were studied.When surface TSLPR is detected at the diagnosis of BCP-ALL, close attention should be given to the search for chromosomal aberrations involving CRLF2 at any level of expression.
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