Targeting RNA and Protein Turnover in Aneuploid Cancers

Summary: Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagues identify RNA and protein turnover as targetable therapeutic vulnerabilities in aneuploid cancers. See related article by Ippolito et al., p. 2532