生物传感器
间质液
电化学
材料科学
化学
纳米技术
生物医学工程
色谱法
电极
内科学
医学
物理化学
作者
Muamer Dervisevic,Lars Esser,Yaping Chen,Marı́a Alba,Beatriz Prieto‐Simón,Nicolas H. Voelcker
标识
DOI:10.1016/j.bios.2024.116995
摘要
The development of point-of-care wearable devices capable of measuring insulin concentration has the potential to significantly improve diabetes management and life quality of diabetic patients. However, the lack of a suitable point-of-care device for personal use makes regular insulin level measurements challenging, in stark contrast to glucose monitoring. Herein, we report an electrochemical transdermal biosensor that utilizes a high-density polymeric microneedle array (MNA) to detect insulin in interstitial fluid (ISF). The biosensor consists of gold-coated polymeric MNA modified with an insulin-selective aptamer, which was used for extraction and electrochemical quantification of the insulin in ISF. In vitro testing of biosensor, performed in artificial ISF (aISF), showed high selectivity for insulin with a linear response between 0.01 nM and 4 nM (sensitivity of ∼65 Ω nM
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