The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

异丙酚 医学 宫腔镜检查 麻醉 外科
作者
Weifeng Shan,Shuying Gao,Mengting Ai,Haiyan Lan,Gongchen Duan,Xiaoli Dong,Qiaomin Xu,Yini Wu,Jimin Wu
出处
期刊:Frontiers in Pharmacology [Frontiers Media]
卷期号:15
标识
DOI:10.3389/fphar.2024.1427755
摘要

Objective Remimazolam besylate and Ciprofol are newer sedatives used in minor surgeries. Propofol is a classic drug mainly used for short surgeries. This trial was conducted to compare the efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopic surgeries. Methods Patients undergoing hysteroscopy were randomly assigned to receive remimazolam besylate (Group R), ciprofol (Group C), or propofol (Group P). A total of 194 patients were assessed for eligibility. One patient in Group P was excluded because the operation had timed out of 60 min. Patients all in Group R、Group C and Group P received an induction dose of 0.2 mg/kg remimazolam besylate、0.4 mg/kg ciprofol、2.0 mg/kg propofol seperately over 30 s. A corresponding dosage of 1 mg/kg/h、0.6–1.2 mg/kg/h and 3.0–6.0 mg/kg/h was given by continuous intravenous infusion to maintain a BIS of 40–60 till the end of the surgery. The incidence rates of body movement, respiratory depression, and adverse effects were compared among the groups. Results The incidence of injection pain was much higher in Group P (64.1%) than that in Group R (3.4%) and Group C (3.2%, both P < 0.001). The onset time was significantly shorter in Group P than that in Group R and Group C (both P < 0.01). The awakening time (MOAA/S score = 3) was longest in Group R, followed by Groups C and Group P ( P < 0.01). The time to complete recovery (MOAA/S score = 5) has no significantly difference between Group C and Group P, whereas the onset time was significantly shorter in Group R ( P < 0.01). The number of body movements was significantly higher in Group R than that in Group C and Group P ( P < 0.01). The incidence of hypotension was significantly lower in Group R than that in Group C and Group P (both P < 0.01). The rate of respiratory inhibition was significantly lower in Group R and Group C than that in Group P (both P < 0.05). Conclusion Considering jointly the safety and efficacy, ciprofol seems to be the best choice for sedation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hello应助zhai采纳,获得10
刚刚
刚刚
似非发布了新的文献求助10
1秒前
摇不滚摇滚完成签到 ,获得积分10
1秒前
独特冰安发布了新的文献求助10
2秒前
内向万天完成签到,获得积分10
2秒前
4秒前
swy发布了新的文献求助10
4秒前
ldjekfj完成签到,获得积分10
4秒前
calico完成签到,获得积分10
4秒前
陈瑶完成签到,获得积分20
5秒前
常常发布了新的文献求助10
6秒前
magicjerry发布了新的文献求助10
7秒前
李治稳发布了新的文献求助10
7秒前
7秒前
lll完成签到,获得积分10
7秒前
李健的粉丝团团长应助swy采纳,获得10
7秒前
积极松鼠完成签到,获得积分10
8秒前
王1发布了新的文献求助10
9秒前
10秒前
爱科研的罗罗完成签到,获得积分10
10秒前
suering发布了新的文献求助50
11秒前
11秒前
猪猪hero应助wjx采纳,获得10
11秒前
失眠无声发布了新的文献求助10
13秒前
yyds完成签到,获得积分10
14秒前
,,,发布了新的文献求助10
14秒前
15秒前
15秒前
orixero应助an采纳,获得10
16秒前
16秒前
16秒前
共享精神应助王梦豪采纳,获得10
17秒前
18秒前
null完成签到,获得积分10
18秒前
19秒前
阳光的梦寒完成签到 ,获得积分10
19秒前
magicjerry完成签到,获得积分10
19秒前
meng发布了新的文献求助10
19秒前
20秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975250
求助须知:如何正确求助?哪些是违规求助? 3519625
关于积分的说明 11199055
捐赠科研通 3255962
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877358
科研通“疑难数据库(出版商)”最低求助积分说明 806298