The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

异丙酚 医学 宫腔镜检查 麻醉 外科
作者
Weifeng Shan,Shuying Gao,Mengting Ai,Haiyan Lan,Gongchen Duan,Xiaoli Dong,Qiaomin Xu,Yini Wu,Jimin Wu
出处
期刊:Frontiers in Pharmacology [Frontiers Media]
卷期号:15
标识
DOI:10.3389/fphar.2024.1427755
摘要

Objective Remimazolam besylate and Ciprofol are newer sedatives used in minor surgeries. Propofol is a classic drug mainly used for short surgeries. This trial was conducted to compare the efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopic surgeries. Methods Patients undergoing hysteroscopy were randomly assigned to receive remimazolam besylate (Group R), ciprofol (Group C), or propofol (Group P). A total of 194 patients were assessed for eligibility. One patient in Group P was excluded because the operation had timed out of 60 min. Patients all in Group R、Group C and Group P received an induction dose of 0.2 mg/kg remimazolam besylate、0.4 mg/kg ciprofol、2.0 mg/kg propofol seperately over 30 s. A corresponding dosage of 1 mg/kg/h、0.6–1.2 mg/kg/h and 3.0–6.0 mg/kg/h was given by continuous intravenous infusion to maintain a BIS of 40–60 till the end of the surgery. The incidence rates of body movement, respiratory depression, and adverse effects were compared among the groups. Results The incidence of injection pain was much higher in Group P (64.1%) than that in Group R (3.4%) and Group C (3.2%, both P < 0.001). The onset time was significantly shorter in Group P than that in Group R and Group C (both P < 0.01). The awakening time (MOAA/S score = 3) was longest in Group R, followed by Groups C and Group P ( P < 0.01). The time to complete recovery (MOAA/S score = 5) has no significantly difference between Group C and Group P, whereas the onset time was significantly shorter in Group R ( P < 0.01). The number of body movements was significantly higher in Group R than that in Group C and Group P ( P < 0.01). The incidence of hypotension was significantly lower in Group R than that in Group C and Group P (both P < 0.01). The rate of respiratory inhibition was significantly lower in Group R and Group C than that in Group P (both P < 0.05). Conclusion Considering jointly the safety and efficacy, ciprofol seems to be the best choice for sedation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
aeyounrz发布了新的文献求助10
刚刚
香蕉觅云应助认真的白易采纳,获得10
刚刚
霸气的冰旋完成签到,获得积分10
刚刚
1秒前
dong应助ayuelei采纳,获得10
1秒前
2秒前
CUI发布了新的文献求助10
2秒前
2秒前
摩卡题目发布了新的文献求助10
2秒前
罗某人发布了新的文献求助10
2秒前
陈思雨发布了新的文献求助10
3秒前
SMG完成签到 ,获得积分10
3秒前
搜集达人应助小兔子乖乖采纳,获得10
4秒前
杭剑成完成签到,获得积分10
4秒前
量子星尘发布了新的文献求助30
5秒前
5秒前
6秒前
喻铁身发布了新的文献求助10
7秒前
lily完成签到,获得积分10
7秒前
松鼠15111完成签到,获得积分10
7秒前
小田发布了新的文献求助10
7秒前
8秒前
9秒前
蜂鸟完成签到,获得积分10
9秒前
森sen完成签到 ,获得积分10
10秒前
小何发布了新的文献求助10
10秒前
11秒前
11秒前
kira完成签到,获得积分10
11秒前
12秒前
12秒前
年薪百万发布了新的文献求助10
12秒前
13秒前
从别后忆相逢完成签到,获得积分10
13秒前
13秒前
王伟发布了新的文献求助10
13秒前
13秒前
14秒前
SMHILU完成签到,获得积分10
14秒前
ak发布了新的文献求助10
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969513
求助须知:如何正确求助?哪些是违规求助? 3514327
关于积分的说明 11173617
捐赠科研通 3249672
什么是DOI,文献DOI怎么找? 1794973
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804836