The oral GnRH antagonists, a new class of drugs in gynecology: from pharmacokinetics to possible clinical applications

Introduction In ovarian steroid-dependent diseases such as uterine fibroids, endometriosis and adenomyosis, oral GnRH antagonists have emerged as new therapeutic alternatives. These oral GnRH antagonists offer key advantages, including oral administration, dose-dependent estrogen suppression and rapid reversibility.