微管蛋白
微管
癌变
抗癌药
癌症
药物开发
药品
药物发现
微管聚合
生物
计算生物学
癌症研究
化学
药理学
生物信息学
细胞生物学
遗传学
作者
Prasanna Anjaneyulu Yakkala,Shaik O. Rahaman,P.S. Lakshmi Soukya,Sajeli Ahil Begum,Ähmed Kamal
标识
DOI:10.1080/14728222.2024.2341630
摘要
Introduction Microtubules play a vital role in cancer therapeutics. They are implicated in tumorigenesis, thus inhibiting tubulin polymerization in cancer cells, and have now become a significant target for anticancer drug development. A plethora of drug molecules has been crafted to influence microtubule dynamics and presently, numerous tubulin inhibitors are being investigated. This review discusses the recently developed inhibitors including natural products, and also examines the preclinical and clinical data of some potential molecules.
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