医学
肺动脉高压
基因敲除
下调和上调
基因沉默
血管平滑肌
激酶
PDZ域
微阵列分析技术
癌症研究
病理
细胞生物学
内科学
生物
基因表达
基因
平滑肌
生物化学
作者
Zsuzsanna Bordán,Róbert Bátori,Stephen Haigh,Xueyi Li,Mary Louise Meadows,Zachary Brown,Madison A. West,Kunzhe Dong,Weihong Han,Yunchao Su,Qian Ma,Yuqing Huo,Jiliang Zhou,Mahmoud Abdelbary,Jennifer C. Sullivan,Neal L. Weintraub,David W. Stepp,Feng Chen,Scott A. Barman,David Fulton
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:2024-04-29
标识
DOI:10.1161/circulationaha.123.067095
摘要
Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling of pulmonary arteries (PA) leading to right ventricle failure and death. Although treatment of PAH has improved, the long-term prognosis for patients remains poor, and more effective targets are needed.
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