摘要
Chapter 21 The laboratory mouse Biology, behaviour, enrichment and welfare: first principles and real solutions for laboratory mice Kathleen R. Pritchett-Corning, Kathleen R. Pritchett-CorningSearch for more papers by this authorJoseph P. Garner, Joseph P. GarnerSearch for more papers by this author Kathleen R. Pritchett-Corning, Kathleen R. Pritchett-CorningSearch for more papers by this authorJoseph P. Garner, Joseph P. GarnerSearch for more papers by this author Book Editor(s):Huw Golledge, Huw Golledge Universities Federation Animal Welfare, UKSearch for more papers by this authorClaire Richardson, Claire Richardson Universities Federation Animal Welfare, UKSearch for more papers by this author First published: 14 March 2024 https://doi.org/10.1002/9781119555278.ch21 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary This chapter illustrates the detailed steps and understanding required to avoid preventable welfare impacts of housing and husbandry, monitor for physical and behavioural health problems and develop a behavioural management plan. The understanding of stress and distress in the context of animal physiology, animal welfare and animal husbandry has advanced considerably in recent years. Mice perceive the world differently than humans, and knowledge and understanding of this is crucial in adapting environments to suit mice as well as troubleshooting mouse behavioural or reproductive issues. Mouse general maintenance behaviour includes ingestive behaviour, sleeping or resting and grooming. Non-infectious diseases of mice are relatively common. The chapter covers mouse breeding and related behaviours. A growing number of behavioural management options are becoming available for mice. References Aasland , K.E. , Skjerve , E. and Smith , A.J. ( 2010 ) Quality of blood samples from the saphenous vein compared with the tail vein during multiple blood sampling of mice . Laboratory Animals , 44 , 25 – 29 . 10.1258/la.2009.009017 CASPubMedWeb of Science®Google Scholar Abolins , S. , King , E.C. , Lazarou , L. , et al . ( 2017 ) The comparative immunology of wild and laboratory mice, Mus musculus domesticus . Nature Communications , 8 , 14811 . 10.1038/ncomms14811 PubMedWeb of Science®Google Scholar Adams , S.C. , Garner , J.P. , Felt , S.A. , et al . ( 2016 ) A "pedi" cures all: toenail trimming and the treatment of ulcerative dermatitis in mice . PLoS One , 11 , e0144871 . 10.1371/journal.pone.0144871 Web of Science®Google Scholar Ader , D.N. , Johnson , S.B. , Huang , S.W. , et al . ( 1991 ) Group size, cage shelf level, and emotionality in non-obese diabetic mice: impact on onset and incidence of IDDM . Psychosomatic Medicine , 53 , 313 – 321 . 10.1097/00006842-199105000-00005 CASPubMedWeb of Science®Google Scholar Ahlgren , J. and Voikar , V. ( 2019 ) Housing mice in the individually ventilated or open cages-does it matter for behavioral phenotype? Genes , Brain and Behavior , 18 , e12564 . 10.1111/gbb.12564 Web of Science®Google Scholar Ahloy-Dallaire , J. , Klein , J.D. , Davis , J.K. , et al . ( 2019 ) Automated monitoring of mouse feeding and body weight for continuous health assessment . Laboratory Animals , 53 , 342 – 351 . 10.1177/0023677218797974 CASPubMedWeb of Science®Google Scholar Ahrens Kress , A.P. , Zhang , Y. , Kaiser-Vry , A.R. , et al . ( 2022 ) A comparison of blood collection techniques in mice and their effects on welfare . Journal of the American Association for Laboratory Animal Science , 61 , 287 – 295 . 10.30802/AALAS-JAALAS-21-000129 Web of Science®Google Scholar Albers , T.M. , Henderson , K.S. , Mulder , G.B. , et al . ( 2023 ) Pathogen prevalence and health monitoring trends in laboratory mice and rats from 2003 to 2020 . Journal of the American Association for Laboratory Animal Science , in press. 10.30802/AALAS-JAALAS-22-000097 Web of Science®Google Scholar Alvarado , C.G. , Franklin , C.L. and Dixon , L.W. ( 2016 ) Retrospective evaluation of nail trimming as a conservative treatment for ulcerative dermatitis in laboratory mice . Journal of the American Association for Laboratory Animal Science , 55 , 462 – 466 . Web of Science®Google Scholar Anderson , K.R. , Haeussler , M. , Watanabe , C. , et al . ( 2018 ) CRISPR off-target analysis in genetically engineered rats and mice . Nature Methods , 15 , 512 – 514 . 10.1038/s41592-018-0011-5 CASPubMedWeb of Science®Google Scholar Arakawa , H. , Arakawa , K. , Blanchard , D.C. , et al . ( 2007 ) Scent marking behavior in male C57BL/6J mice: sexual and developmental determination . Behavioural Brain Research , 182 , 73 – 79 . 10.1016/j.bbr.2007.05.007 PubMedWeb of Science®Google Scholar Arakawa , H. , Cruz , S. and Deak , T. ( 2011 ) From models to mechanisms: odorant communication as a key determinant of social behavior in rodents during illness-associated states . Neuroscience & Biobehavioral Reviews , 35 , 1916 – 1928 . 10.1016/j.neubiorev.2011.03.007 PubMedWeb of Science®Google Scholar Archer , J. ( 1973 ) Tests for emotionality in rats and mice: a review . Animal Behaviour , 21 , 205 – 235 . 10.1016/S0003-3472(73)80065-X CASPubMedWeb of Science®Google Scholar Asaba , A. , Osakada , T. , Touhara , K. , et al . ( 2017 ) Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity . Hormones and Behavior , 94 , 53 – 60 . 10.1016/j.yhbeh.2017.06.006 CASPubMedWeb of Science®Google Scholar Atanasov , N.A. , Sargent , J.L. , Parmigiani , J.P. , et al . ( 2015 ) Characterization of train-induced vibration and its effect on fecal corticosterone metabolites in mice . Journal of the American Association for Laboratory Animal Science , 54 , 737 – 744 . Web of Science®Google Scholar Attanasio , C. , D'angelo , L. and Corsi , L. ( 2022 ) Chapter 5 – methods of handling and procedures . In: Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU . Eds G. Dal Negro and S Sabbioni . Academic Press , London . 10.1016/B978-0-12-821180-9.00001-5 Google Scholar Ayadi , A. , Ferrand , G. , Cruz , I.G.D. , et al . ( 2011 ) Mouse breeding and colony management . Current Protocols in Mouse Biology , 1 , 239 – 264 . 10.1002/9780470942390.mo100214 PubMedGoogle Scholar Bachmanov , A.A. , Reed , D.R. , Beauchamp , G.K. , et al . ( 2002 ) Food intake, water intake, and drinking spout side preference of 28 mouse strains . Behavior Genetics , 32 , 435 – 443 . 10.1023/A:1020884312053 CASPubMedWeb of Science®Google Scholar D.G. Baker (ed.) ( 2007 ) Flynn's Parasites of Laboratory Animals . Blackwell , Ames . 10.1002/9780470344552 Google Scholar Barabas , A.J. , Aryal , U.K. and Gaskill , B.N. ( 2022a ) Protein profiles from used nesting material, saliva, and urine correspond with social behavior in group housed male mice, Mus musculus . Journal of Proteomics , 266 , 104685 . 10.1016/j.jprot.2022.104685 CASWeb of Science®Google Scholar Barabas , A.J. , Darbyshire , A.K. , Schlegel , S.L. , et al . ( 2022b ) Evaluation of ambient sound, vibration, and light in rodent housing rooms . Journal of the American Association for Laboratory Animal Science , 61 , 660 – 671 . 10.30802/AALAS-JAALAS-22-000040 Web of Science®Google Scholar Barabas , A.J. , Lucas , J.R. , Erasmus , M.A. , et al . ( 2021a ) Who's the boss? Assessing convergent validity of aggression based dominance measures in male laboratory mice, Mus musculus . Frontiers in Veterinary Science , 8 , 695948 . 10.3389/fvets.2021.695948 Web of Science®Google Scholar Barabas , A.J. , Soini , H.A. , Novotny , M.V. , et al . ( 2022c ) Assessing the effect of compounds from plantar foot sweat, nesting material, and urine on social behavior in male mice, Mus musculus . PLoS One , 17 , e0276844 . 10.1371/journal.pone.0276844 CASWeb of Science®Google Scholar Barabas , A.J. , Soini , H.A. , Novotny , M.V. , et al . ( 2021b ) Compounds from plantar foot sweat, nesting material, and urine show strain patterns associated with agonistic and affiliative behaviors in group housed male mice, Mus musculus . PLoS One , 16 , e0251416 . 10.1371/journal.pone.0251416 CASWeb of Science®Google Scholar Baumans , V. , Schlingmann , F. , Vonck , M. , et al . ( 2002 ) Individually ventilated cages: beneficial for mice and men? Contemporary Topics in Laboratory Animal Science , 41 , 13 – 19 . PubMedWeb of Science®Google Scholar Beck , J.A. , Lloyd , S. , Hafezparast , M. , et al . ( 2000 ) Genealogies of mouse inbred strains . Nature Genetics , 24 , 23 – 25 . 10.1038/71641 CASPubMedWeb of Science®Google Scholar Beckett , J. ( 2015 ) How to suture – types and patterns in veterinary surgery . The Veterinary Nurse , 6 , 620 – 628 . 10.12968/vetn.2015.6.10.620 Google Scholar Bedford , N.L. and Hoekstra , H.E. ( 2015 ) Peromyscus mice as a model for studying natural variation . eLife , 4 , e06813 . 10.7554/eLife.06813 PubMedWeb of Science®Google Scholar Begley , C.G. ( 2013 ) Six red flags for suspect work . Nature , 497 , 433 – 434 . 10.1038/497433a CASPubMedWeb of Science®Google Scholar Bekkevold , C.M. , Robertson , K.L. , Reinhard , M.K. , et al . ( 2013 ) Dehydration parameters and standards for laboratory mice . Journal of the American Association for Laboratory Animal Science , 52 , 233 – 239 . CASPubMedWeb of Science®Google Scholar Benavides , F. , Rülicke , T. , Prins , J.-B. , et al . ( 2020 ) Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA working group report . Laboratory Animals , 54 , 135 – 148 . 10.1177/0023677219867719 CASPubMedWeb of Science®Google Scholar Benga , L. , Sager , M. and Christensen , H. ( 2018 ) From the [ Pasteurella ] pneumotropica complex to Rodentibacter spp.: an update on [ Pasteurella ] pneumotropica . Veterinary Microbiology , 217 , 121 – 134 . 10.1016/j.vetmic.2018.03.011 PubMedWeb of Science®Google Scholar Bennett , K. and Lewis , K. ( 2022 ) Sedation and anesthesia in rodents . Veterinary Clinics: Exotic Animal Practice , 25 , 211 – 255 . 10.1016/j.cvex.2021.08.013 Google Scholar Bechard , A. and Mason , G. ( 2010 ). Leaving home: a study of laboratory mouse pup independence . Applied Animal Behaviour Science , 125 , 181 – 188 . 10.1016/j.applanim.2010.04.006 Web of Science®Google Scholar Bernal , J. , Baldwin , M. , Gleason , T. , et al . ( 2009 ) Guidelines for rodent survival surgery . Journal of Investigative Surgery , 22 , 445 – 451 . 10.3109/08941930903396412 Web of Science®Google Scholar Berridge , K.C. , Fentress , J.C. and Parr , H. ( 1987 ) Natural syntax rules control action sequence of rats . Behavioural Brain Research , 23 , 59 – 68 . 10.1016/0166-4328(87)90242-7 CASPubMedWeb of Science®Google Scholar Berry , R.J. ( 1970 ) The natural history of the house mouse . Field Studies , 3 , 219 – 262 . Google Scholar Berry , R.J. ( 1981 ) Town mouse, country mouse – adaptation and adaptability in Mus domesticus ( M. musculus domesticus ) . Mammal Review , 11 , 91 – 136 . 10.1111/j.1365-2907.1981.tb00001.x Web of Science®Google Scholar Berry , R.J. and Bronson , F.H. ( 1992 ) Life-history and bioeconomy of the house mouse . Biological Reviews , 67 , 519 – 550 . 10.1111/j.1469-185X.1992.tb01192.x CASPubMedWeb of Science®Google Scholar Beura , L.K. , Hamilton , S.E. , Bi , K. , et al . ( 2016 ) Normalizing the environment recapitulates adult human immune traits in laboratory mice . Nature , 532 , 512 – 516 . 10.1038/nature17655 CASPubMedWeb of Science®Google Scholar Biggers , J.D. , Curnow , R.N. , Finn , C.A. , et al . ( 1963 ) Regulation of the gestation period in mice . Journal of Reproduction and Infertility , 6 , 125 – 138 . 10.1530/jrf.0.0060125 CASGoogle Scholar Bittner , J.J. ( 1941 ) The preservation by freezing and drying in vacuo of the milk-influence for the development of breast cancer in mice . Science , 93 , 527 – 528 . 10.1126/science.93.2422.527 CASPubMedWeb of Science®Google Scholar Blankenberger , W.B. , Weber , E.M. , Chu , D.K. , et al . ( 2018 ) Breaking up is hard to do: does splitting cages of mice reduce aggression? Applied Animal Behaviour Science , 206 , 94 – 101 . 10.1016/j.applanim.2018.06.003 Web of Science®Google Scholar Bracken , T.C. , Cooper , C.A. , Ali , Z. , et al . ( 2017 ) Helicobacter infection significantly alters pregnancy success in laboratory mice . Journal of the American Association for Laboratory Animal Science , 56 , 322 – 329 . PubMedWeb of Science®Google Scholar Braden , G.C. , Rasmussen , S. , Monette , S. , et al . ( 2017 ) Eff