The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community‐based population: Results based on high‐resolution magnetic resonance imaging

国际民航组织 医学 冲程(发动机) 磁共振成像 无症状的 危险系数 置信区间 内科学 狭窄 心脏病学 人口 比例危险模型 磁共振血管造影 放射科 机械工程 生物化学 化学 环境卫生 工程类 基因
作者
Shengde Li,Mingyu Tang,Dingding Zhang,Fei Han,Lixin Zhou,Ming Yao,Mingli Li,Liying Cui,Shuyang Zhang,Bin Peng,Zhengyu Jin,Yi‐Cheng Zhu,Jun Ni
出处
期刊:European Journal of Neurology [Wiley]
卷期号:30 (12): 3761-3771 被引量:7
标识
DOI:10.1111/ene.16057
摘要

Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke in China, but the prevalence and prognosis of asymptomatic ICAD detected using high-resolution magnetic resonance imaging (HR-MRI) is largely unknown. The aim of this study was to investigate the prevalence and prognosis in order to guide neurologists in interpreting ICAD detected on HR-MRI.We included stroke-free participants from a community-based prospective cohort (Shunyi study participants) who underwent HR-MRI between July 2014 and April 2016. The participants were divided into two groups: those with or without ICAD (ICAD+ and ICAD- , respectively). ICAD included intracranial artery stenosis and non-stenotic plaque. The primary outcome was ischemic stroke. Cox proportional hazard models were used to evaluate the association between ICAD and event outcomes.A total of 1060 stroke-free participants evaluated by HR-MRI were included from the Shunyi study. The median age at HR-MRI was 56 years and 64.7% were female. The ICAD prevalence was 36.3% (n = 385). The ICAD+ group was older and had more cerebrovascular risk factors. The rates of ischemic stroke in the ICAD- and ICAD+ groups were 1.3% (n = 9) and 5.2% (n = 20), respectively, with a median follow-up time of 54 months. ICAD was associated with an increased risk of ischemic stroke in the unadjusted and adjusted Cox models, with hazard ratios of 4.12 (95% confidence interval [CI] 1.87-9.05) and 2.50 (95% CI 1.05-5.94), respectively. The greatest risk of an event outcome was observed in participants with ≥70% stenosis or occlusion. The features of high-risk plaques were also identified.We found that ICAD detected using HR-MRI increases the long-term risk of a first-ever ischemic stroke in a stroke-free population, suggesting that the current primary prevention protocol of stroke awaits further optimization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
搜集达人应助JW采纳,获得10
1秒前
???完成签到,获得积分10
3秒前
优秀的白曼完成签到,获得积分10
5秒前
王小西发布了新的文献求助10
6秒前
碧蓝莫言完成签到 ,获得积分10
8秒前
清璃完成签到 ,获得积分10
9秒前
虚心的寒梦完成签到,获得积分10
9秒前
秋秋发布了新的文献求助10
9秒前
kkk完成签到,获得积分10
11秒前
bnhh完成签到,获得积分10
11秒前
Betty应助lindahuang采纳,获得10
12秒前
ilk666完成签到,获得积分10
13秒前
小王同学发布了新的文献求助10
13秒前
奶油布丁完成签到,获得积分10
16秒前
酶没美镁完成签到,获得积分10
16秒前
天天快乐应助李治海采纳,获得10
17秒前
星辰大海应助lll采纳,获得10
17秒前
龙1完成签到,获得积分10
17秒前
yzhilson完成签到 ,获得积分10
18秒前
量子星尘发布了新的文献求助10
19秒前
RRR完成签到,获得积分10
20秒前
金色天际线完成签到,获得积分10
21秒前
明ming到此一游完成签到 ,获得积分10
24秒前
pophoo完成签到,获得积分10
24秒前
11发布了新的文献求助10
25秒前
酷炫的黄豆完成签到 ,获得积分10
26秒前
hzz完成签到,获得积分10
29秒前
30秒前
深情安青应助科研通管家采纳,获得10
30秒前
fang应助科研通管家采纳,获得10
30秒前
Passskd发布了新的文献求助10
30秒前
fang应助科研通管家采纳,获得10
30秒前
30秒前
30秒前
30秒前
彭于晏应助科研通管家采纳,获得10
30秒前
山野村夫应助科研通管家采纳,获得10
30秒前
Singularity应助科研通管家采纳,获得10
30秒前
隐形曼青应助科研通管家采纳,获得10
30秒前
Mars应助科研通管家采纳,获得10
30秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029