Access to Amides and Lactams via Pyridotriazole as a Transformable Directing Group

Amide and lactam frameworks were synthesized via an efficient two-step strategy. In this protocol, pyridotriazoles were first treated with isocyanates to form the corresponding amides, which were found to be sufficiently reactive to undergo subsequent intramolecular N–H insertion in the absence of any additional reagents or catalysts.