医学
白藜芦醇
糖尿病
内科学
肾功能
内分泌学
药理学
作者
Colin J. Gimblet,Nicholas T. Kruse,Katharine Geasland,Jeni Michelson,Mingyao Sun,Safur Rehman Mandukhail,Linder Wendt,Patrick Ten Eyck,Gary L. Pierce,Diana Jalal
出处
期刊:Clinical Journal of The American Society of Nephrology
[American Society of Nephrology]
日期:2023-10-16
被引量:3
标识
DOI:10.2215/cjn.0000000000000337
摘要
Background Patients with CKD and diabetes are at higher risk of developing cardiovascular disease, in part, because of impaired endothelial function. Cardioprotective compounds such as resveratrol could improve endothelial function and attenuate the cardiovascular burden in patients with CKD and diabetes. We hypothesized that resveratrol supplementation would improve endothelial function in patients with CKD and diabetes. Methods Twenty-eight adults aged 68±7 years (84% men) with stage 3 CKD and diabetes were enrolled in a randomized, double-blind, placebo-controlled, crossover study to investigate the effects of 6-week resveratrol supplementation (400 mg/d) on endothelial function. Endothelial function was determined through brachial artery flow-mediated dilation. Results The mean values for eGFR and hemoglobin A 1c were 40±9 ml/min per 1.73 m 2 and 7.36%±0.72%, respectively. Compared with placebo, resveratrol supplementation increased flow-mediated dilation (ratio of geometric mean changes and 95% confidence interval for between-group comparisons, 1.43 (1.15 to 1.77); P value = 0.001). eGFR, hemoglobin A 1c , BP, and nitroglycerin-mediated dilation were unchanged with resveratrol or placebo ( P = 0.15), suggesting the observed change in flow-mediated dilation was likely independent of changes in traditional cardiovascular risk factors. Conclusions Resveratrol supplementation improved endothelial function in patients with CKD and diabetes. Clinical Trial registry name and registration number Resveratrol and Vascular Function in CKD, NCT03597568.
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