J‐shaped association between systemic immune‐inflammation index and periodontitis: Results from NHANES 2009–2014

牙周炎 医学 全国健康与营养检查调查 牙周病学 逻辑回归 内科学 优势比 临床附着丧失 胃肠病学 牙科 人口 环境卫生
作者
Ruoyan Cao,Chen Li,Fengxue Geng,Yaping Pan
出处
期刊:Journal of Periodontology [Wiley]
被引量:12
标识
DOI:10.1002/jper.23-0260
摘要

Abstract Background To examine the relationship between the systemic immune‐inflammation index (SII) and periodontitis and to investigate possible effect modifiers. Methods Data used in the present cross‐sectional study are from the National Health and Nutrition Examination Survey (NHANES) 2009–2014 ( N = 10,301). The SII was calculated using the following formula: (neutrophils count × platelet count)/lymphocytes count. The category of periodontitis was defined by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) classification. We employed natural cubic spline and multivariable logistic regression analyses to evaluate the associations of the SII with periodontitis. Results The associations between SII and periodontal health followed a J‐shape ( p < 0.001). The risk of periodontitis tended to reduce with the increment of log 2 (SII) in participants with log 2 (SII) ≤ 8.66 (odds radio [OR] = 0.83; 95% CI: 0.69–0.999), especially among non‐Hispanic Whites (OR = 0.70; 95% CI: 0.52–0.95), and increased with the increment of log 2 (SII) in participants with log 2 (SII) > 8.66 (OR = 1.19; 95% CI: 1.02–1.38). A similar trend was also observed between the SII and the number of sites with probing pocket depth (PPD) ≥4 mm and clinical attachment loss (CAL) ≥ 3 or 5 mm. Furthermore, we found a significantly stronger correlation between lymphocytes and either neutrophils or platelets in individuals with log 2 (SII) > 8.66, as opposed to those with log 2 (SII) ≤ 8.66. Conclusions There is a J‐shaped association between SII and periodontitis in US adults, with an inflection point of log 2 (SII) at 8.66, which may provide potential adjunctive treatment strategies for periodontitis with different immune response states. Further prospective trials are still required to confirm our findings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
NZH关闭了NZH文献求助
刚刚
妍宝贝给妍宝贝的求助进行了留言
5秒前
大气的水彤完成签到,获得积分10
5秒前
SSS完成签到 ,获得积分10
6秒前
呆瓜完成签到,获得积分10
10秒前
10秒前
心灵美的不愁完成签到,获得积分10
13秒前
陈敏完成签到 ,获得积分10
13秒前
么么叽发布了新的文献求助10
13秒前
16秒前
领导范儿应助NZH采纳,获得10
20秒前
刘能能完成签到,获得积分10
22秒前
喜欢玩辅助完成签到,获得积分10
23秒前
Lucas应助彪壮的小五采纳,获得10
24秒前
haidayu完成签到,获得积分10
25秒前
25秒前
hcy完成签到,获得积分10
25秒前
spark810应助zed66采纳,获得30
26秒前
26秒前
TRTHHRTZ完成签到,获得积分10
29秒前
无私诗云发布了新的文献求助10
29秒前
WZQ完成签到,获得积分10
31秒前
鸡蛋饼波比完成签到 ,获得积分10
32秒前
33秒前
SYUE发布了新的文献求助30
33秒前
华仔应助Xdz采纳,获得10
35秒前
37秒前
37秒前
科小银发布了新的文献求助10
37秒前
Niki发布了新的文献求助10
40秒前
ZhenpuWang发布了新的文献求助10
41秒前
41秒前
43秒前
44秒前
木棉发布了新的文献求助10
45秒前
46秒前
47秒前
Xdz发布了新的文献求助10
48秒前
科小银完成签到,获得积分10
49秒前
个性的紫菜应助龙龙采纳,获得20
50秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
A Dissection Guide & Atlas to the Rabbit 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3082501
求助须知:如何正确求助?哪些是违规求助? 2735655
关于积分的说明 7538441
捐赠科研通 2385263
什么是DOI,文献DOI怎么找? 1264761
科研通“疑难数据库(出版商)”最低求助积分说明 612786
版权声明 597665