甲状腺癌
医学
甲状腺结节
甲状腺癌
小桶
甲状腺炎
甲状腺
甲状腺乳突癌
内科学
病理
生物标志物
免疫组织化学
结核(地质)
基因本体论
基因
化学
生物
基因表达
生物化学
古生物学
作者
Yan Zhang,Qiao Zhang,Yingying Zheng,Jiaxi Chen,Nian Liu,Бо Лю,Wengang Song
标识
DOI:10.4103/jcrt.jcrt_919_23
摘要
ABSTRACT Background: Hashimoto’s thyroiditis (HT) is an independent risk factor for papillary thyroid carcinoma (PTC), but the underlying mechanism remains unknown. The incidence of PTC in patients with HT is significantly elevated, and the presence of both HT and PTC contributes to a higher rate of misdiagnosis. Materials and Methods: Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the thyroid nodule gene chip dataset from GEO Datasets. Serum and clinical data from 191 patients with thyroid nodules at the affiliated hospital were collected for analysis. Experimental techniques, including real-time quantitative PCR, ELISA, immunohistochemistry (IHC), and enzyme activity detection, were used to measure the level of dipeptidyl peptidase 4 (DPP4) in thyroid nodule tissues and serum. Results: Thyroid nodules in patients with HT and PTC exhibit high levels of DPP4, along with elevated concentrations of soluble DPP4 in the serum. These findings demonstrate the potential predictive value of soluble DPP4 for PTC diagnosis. Conclusions: The concentration and enzymatic activity of soluble DPP4 in serum can serve as diagnostic biomarkers for patients with HT-associated PTC.
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