Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study

全基因组关联研究 疾病 连锁不平衡 遗传关联 遗传学 单倍型 人口 优势比 生物 医学 等位基因 单核苷酸多态性 基因型 基因 病理 环境卫生
作者
Mie Rizig,Sara Bandrés‐Ciga,Mary B. Makarious,Oluwadamilola O. Ojo,Peter Wild Crea,Oladunni Abiodun,Kristin Levine,Sani Abubakar,Charles Achoru,Dan Vitale,Olaleye Adeniji,Osigwe P. Agabi,Mathew J. Koretsky,Uchechi Agulanna,Deborah J. Hall,Rufus Akinyemi,Tao Xie,Mohammed Ali,Ejaz A. Shamim,Ifeyinwa Ani‐Osheku,Mahesh Padmanaban,Ohwotemu Arigbodi,David G. Standaert,Abiodun Bello,Marissa Dean,Cyril Erameh,Inas Elsayed,Temitope Farombi,Olaitan Okunoye,Bimbo Fawale,Kimberley J Billingsley,Frank Imarhiagbe,Pilar Álvarez Jerez,Emmanuel Iwuozo,Breeana Baker,Morenikeji Komolafe,Laksh Malik,Paul Nwani,Kensuke Daida,Ernest Nwazor,Abigail Miano‐Burkhardt,Yakub Nyandaiti,Zih‐Hua Fang,Yahaya Obiabo,Jillian H. Kluss,Olanike Odeniyi,Dena Hernández,Francis Odiase,Nahid Tayebi,FI Ojini,Ellen Sidranksy,Gerald Onwuegbuzie,Andrea D'Souza,Godwin Osaigbovo,Bahafta Berhe,Nosakhare Osemwegie,Xylena Reed,Olajumoke Oshinaike,Hampton L. Leonard,Folajimi Otubogun,Chelsea X. Alvarado,Shyngle Oyakhire,Simon Ozomma,Sarah Samuel,Funmilola Tolulope Taiwo,Kolawole Wahab,Yusuf Zubair,Hirotaka Iwaki,Jonggeol Jeffrey Kim,Huw R. Morris,John Hardy,Mike A. Nalls,Karl Heilbron,Lucy Norcliffe‐Kaufmann,Cornelis Blauwendraat,Henry Houlden,Andrew Singleton,Njideka Okubadejo,Njideka Okubadejo,Oluwadamilola O. Ojo,Oladunni Abiodun,Charles Achoru,Osigwe P. Agabi,Uchechi Agulanna,Rufus Akinyemi,Mohammed Ali,Ifeyinwa Ani‐Osheku,Ohwotemu Arigbodi,Abiodun Bello,Cyril Erameh,Temitope Farombi,Bimbo Fawale,Frank Imarhiagbe,Emmanuel Iwuozo,Morenikeji Komolafe,Paul Nwani,Ernest Nwazor,Yakub Nyandaiti,Yahaya Obiabo,Olanike Odeniyi,Francis Odiase,FI Ojini,Gerald Onwuegbuzie,Godwin Osaigbovo,Nosakhare Osemwegie,Olajumoke Oshinaike,Folajimi Otubogun,Shyngle Oyakhire,Simon Ozomma,Sarah Samuel,Funmilola T. Taiwo,Kolawole Wahab,Yusuf Zubair,Daniel Gams Massi,Eric Gueumekane Bila Lamou,Leonard N. Nfor,Mélanie Annick Magnerou,Yannick Fogang Fogoum,Ali Shalash,Hassan El-FawaI,Eman M. Khedr,Gharib Fawi,Mohamed Abdelhalim Eltantawi,Mohamed Salama,Shaimaa I El-Jaafary,Sherifa A. Hamed,Abenet Tafesse Mengesha,Biniyam A. Ayele,Dereje Melka Oda,Yared Zenebe Zewde,Yohanesse Debebe Gelan,Albert AkpaIu,Augustina Charway‐Felli,Fred Stephen Sarfo,Patrick Adjei,Vida Obese,A Bocoum,Abdou Koïta,Cheick O. Guinto,Toumany Coulibaly,Youssoufa Maiga,Zaynab Kone,Abiodun Bell,Osigwe P. Agabi,Akintunde A. Adebowale,John E. Akpekpe,Alagoma lyagba,Ali Mohammed Wulgo,Ifeyinwa Ani‐Osheku,Babawale Arabambi,Charles Achoru,Christian Agu,Cyril Erameh,Emmanuel Iwuozo,Ernest Nwazor,Bimbo Fawale,Folajimi Otubogun,Francis Odiase,Franklin O. Dike,Ismail O. Ishola,Kolawole Wahab,Kehinde Abiodun,Morenikeji Komolafe,Njideka Okubadejo,Yahaya Obiabo,Ohwotemu Arigbodi,Olajumoke Oshinaike,Nosakhare Osemwegie,Oluchi Ekenze,Oluwadamilola O. Ojo,Paul Agabi Osigwe,Paul Nwani,Salisu A. Balarabe,Sani Abubakar,Uduak Williams,Oladunni Abiodun,Yusuf Zubair,Maouly Fall,Alassane Mamadou Diop,Ewodo Touna Hilaire Dominique,Andre Mochan,Girish Modi,Saiesha Dindayal,Eman Ali Awadelkareem,Inas Elsayed,Maha Dahawi,Mosab Ali Awadelkareem,Sarah Misbah,Brighton Mushengez,Henrika Kimambo,Leonard Msango,Philip Adebayo,Kigocha OKeng,Marieke Diekker,Sarah Urassa,Riadh Gouider,Mouna Ben Djebara,Amina Gargouri,Imen Kacem,Amina Nasri,Saloua Mrabet,Ikram Sghaier,Imen Mkada,Masharip Atadzhanov,Lorraine Chishimba,Mie Rizig,Fatumah Jama,Olaitan Okunoye,John Hardy,Henry Houlden,Andrew Singleton,Mike A. Nalls,Ejaz A. Shamim,Cabell Jonas,Jared Williamson,Deborah J. Hall,Marc Rosenbaum,Staci Davis,Marissa Dean,Candace Cromer,Jenna Smith,Lauren Ruffrage,J. David Richardson,Rebeka Sipma,Tao Xie,Manesh Padmanaban,Natalie Warren,Tomas Mercado,Elizabeth A. Disbrow,Brian Chauppeta,Fermine Thomas-Dean,Jamie Toms,Katelyn Lofton,Ashley Rawls,Kyle Rizer,Nieci Black,Justin Solle,A. O'Grady,Todd Sherer,Brian Fiske,A. Nazlı Başak,Ai Huey Tan,Alastair Noyce,Albert Akpalu,Alberto J. Espay,Alejandro Martínez-Carrasco,Alex Medina,Alexander Zimprich,Alexis Brice,Altynay Karimova,Álvaro Hernández-Flores,A. O'Grady,Anastasia Illarionova,Andrea Quattrone,Andrew Singleton,Andrew K. Sobering,Angel Viñuela,Arinola Sanyaolu,Artur Francisco Schumacher Schuh,Asha Kishore,Azlina Ahmad‐Annuar,Bashayer Al Mubarak,Beisha Tang,Benjamin Pizarro Galleguillos,Beomseok Jeon,Bernadette Siddiqi,Bradford Casey,Brian Fiske,Brit Mollenhauer,Cabell Jonas,Camille Carroll,Carlos Roberto de Mello Rieder,Caroline B. Pantazis,Charisse Comart,Chin‐Hsien Lin,Christine Klein,Claire Bale,Claire E. Shepherd,Claire E. Wegel,Cornelis Blauwendraat,Dan Vitale,Daniel Martínez-Ramírez,Deborah J. Hall,Dena Hernández,Divya KP,Duan Nguyen,Edward A. Fon,Efthymios Dadiotis,Ejaz A. Shamim,Ekemini Riley,Е. А. Яковенко,Ellie Stafford,Emilia Gatto,Enza Maria Valente,Eva‐Juliane Vollstedt,Faraz Faghri,Gençer Genç,Georgia Xiromerisiou,Georgios Hadjigorgiou,Germaine Hiu-Fai Chan,Gonzálo Arboleda,Gulnaz Kaishibayeva,Günter U. Höglinger,Hampton L. Leonard,Harutyun Madoev,Henry Houlden,Hirotaka Iwaki,Honglei Chen,Hsiu-Chuan Wu,Huifang Shang,Huw R. Morris,Ignacio Mata,Ignacio Juan Keller Sarmiento,Ioannis E. Dagklis,Ioannis Tarnanas,Jan Aasly,Janet Hoenicka,Jared Williamson,Jean‐Christophe Corvol,Jia Nee Foo,Jifeng Guo,Johanna Junker,John Hardy,Jonathan Carr,Jonggeol Jeff Kim,Jorge Luís Orozco,Joseph Jankovic,Joshua Shulman,Julie Hunter,Justin Solle,Kaileigh Murphy,Karen Nuytemans,Karl Kieburtz,Katja Lohmann,Kenneth Marek,Kin Ying Mok,Kishore R. Kumar,Kristin Levine,Lana M. Chahine,Lara M. Lange,Lasse Pihlstrøm,Laurel A. Screven,Leonidas Stefanis,Lisa M. Shulman,Luca Marsili,Lucilla Parnetti,Maggie Kuhl,Manabu Funayama,Manu Sharma,Manuela Tan,Marcelo A. Kauffman,Marcelo Miranda,M. Leonor Bustamante,María Stamelou,Maria Teresa Periñan Tocino,Mario Cornejo‐Olivas,Marissa Dean,Marlene Jiménez-Del-Río,Mary B. Makarious,Masharip Atadzhanov,Mathew J. Koretsky,Mayela Rodríguez‐Violante,Melina Ellis,Micol Avenali,Mie Rizig,Miguel E. Rentería,Miguel z Inca-Martines,Mike A. Nalls,Norlinah Mohamed Ibrahim,Mohamed Salama,Muhammad Umair,Nancy Y. Ip,Naomi Louie,Nelson Yuk-Fai Cheung,Niccolò E. Mencacci,Nicholas Wood,Nigel Williams,Njideka Okubadejo,Nobutaka Hattori,Nor Azian Abdul Murad,Norlinah Mohamed Ibrahim,Olaitan Okunoye,Oluwadamilola O. Ojo,Oury Monchi,Özgür Öztop Çakmak,Patricio Öztop Çakmak Öztop Çakmak,Patrick A. Lewis,Pau Pástor,Paula Reyes‐Pérez,Paula Saffie Awad,Pedro Chaná,Phillip Chan,Pin-Jui Kung,Piu Chan,Pramod Kumar Pal,Prashanth Lingappa Kukkle,Rajeev Ojha,Rauan Kaiyrzhanov,Rejko Krüger,Rim Amouri,Rimona S. Weil,Roopa Rajan,Roy N. Alcalay,Ruey‐Meei Wu,Rupam Borgohain,Samia Ben Sassi,Samson Khachatryan,Sara Bandrés‐Ciga,Sarah El-Sadig,Serena Wu,Sergiu Groppa,Shahrul Azmin,Shen‐Yang Lim,Shoaib Ur-Rehman,Sibel Ertan,Simon Stott,Simona Jasaitye,Sohini Chowdhury,Sonya B. Dumanis,Soraya Bardien,Steven Lubbe,Sulev Kõks,Sumit Dey,Tao Xie,Tatiana Foroud,Ted Fon,Thomas Beach,Thomas Gasser,Tim Anderson,Toan Nguyen,Todd Sherer,Tommaso Schirinzi,Tomotaka Shiraishi,Toni L. Pitcher,Vida Obese,Vítor Tumas,Wael Mohamed,Walaa A. Kamel,Wei Luo,Xiaopu Zhou,Yared Zenebe Zewde,Yeajin Song,Yi Wen,Yih‐Ru Wu,Yun Joong Kim,Zaruhi Tavadyan,Zih‐Hua Fang
出处
期刊:Lancet Neurology [Elsevier]
卷期号:22 (11): 1015-1025 被引量:47
标识
DOI:10.1016/s1474-4422(23)00283-1
摘要

An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations.
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