免疫抑制
基因敲除
抗原
免疫学
肺
医学
癌症研究
生物
细胞培养
内科学
遗传学
作者
Constança Figueiredo,Chen Chen,J. Salman,Marco Carvalho Oliveira,Thierry Siemeni Monthé,Klaus Höffler,Tamina Rother,Karolin Hacker,Emilio Valdivia,Olena Pogozhykh,Sabine E. Hammer,W. Sommer,Yuliia Yuzefovych,Nadine Wenzel,Axel Haverich,G. Warnecke,Rainer Blasczyk
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-17
卷期号:16 (756)
标识
DOI:10.1126/scitranslmed.adi9548
摘要
Immune rejection remains the major obstacle to long-term survival of allogeneic lung transplants. The expression of major histocompatibility complex molecules and minor histocompatibility antigens triggers allogeneic immune responses that can lead to allograft rejection. Transplant outcomes therefore depend on long-term immunosuppression, which is associated with severe side effects. To address this problem, we investigated the effect of genetically engineered transplants with permanently down-regulated swine leukocyte antigen (SLA) expression to prevent rejection in a porcine allogeneic lung transplantation (LTx) model. Minipig donor lungs with unmodified SLA expression (control group,
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