收缩性
调制(音乐)
细胞生物学
化学
内科学
生物
内分泌学
医学
物理
声学
作者
André Luís Lima Monteiro,Marcos Eliezeck,Sérgio Scalzo,Mário Morais Silva,Bruno de Lima Sanches,Kathleen Ferreira,Maristela O. Poletini,Rodrigo A. Peliciari‐Garcia,Stefany B.A. Cau,Robson A.S. Santos,Sílvia Guatimosim
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-08-19
标识
DOI:10.1152/ajpcell.00049.2024
摘要
The renin-angiotensin system (RAS) is comprised of a series of peptides, receptors, and enzymes that play a pivotal role in maintaining cardiovascular homeostasis. Among the most important players in this system are the Angiotensin-II and Angiotensin-(1-7) peptides. Our group has recently demonstrated that alamandine (ALA), a peptide with structural and functional similarities to Angiotensin-(1-7), interacts with cardiomyocytes, enhancing contractility via the Mas-related G protein-coupled receptor member D (MrgD). It is currently unknown whether this modulation varies along the distinct phases of the day. To address this issue, we assessed the ALA-induced contractility response of cardiomyocytes from mice at four Zeitgeber times (ZTs). At ZT2 (light phase), ALA enhanced cardiomyocyte shortening in an MrgD receptor-dependent manner, which was associated with NO production. At ZT14 (dark phase), ALA induced a negative modulation on the cardiomyocyte contraction. β-Alanine, an MrgD agonist, reproduced the time-of-day effects of ALA on myocyte shortening. L-N
科研通智能强力驱动
Strongly Powered by AbleSci AI