生物
抗原
免疫学
细胞
细胞生物学
计算生物学
遗传学
作者
Ranit Kedmi,Dan R. Littman
出处
期刊:Immunity
[Elsevier]
日期:2024-10-01
卷期号:57 (10): 2269-2279
标识
DOI:10.1016/j.immuni.2024.09.011
摘要
The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, non-inflammatory responses. This process requires antigen-presenting cells (APCs) that induce T cells with either regulatory or effector functions. Compromised APC function disrupts the T cell balance, leading to inflammation and dysbiosis. Although their precise identities continue to be debated, it has become clear that multiple APC lineages direct the differentiation of distinct microbiota-specific CD4
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