奎宁
金鸡纳
鹳
微观世界
历史
化学
生态学
有机化学
疟疾
生物
环境化学
免疫学
对映选择合成
催化作用
标识
DOI:10.1002/chem.202403021
摘要
The year 2024 marks the 80th anniversary of the landmark formal synthesis of (±)‐quinine completed by Woodward and Doering. This article examines the evolution of approaches to access this storied Cinchona alkaloid natural product which represent a microcosm the progress that has been made in organic synthesis over the past ~170 years. Seminal contributions led by Pasteur, Rabe, Woodward, Uskoković, Stork, Jacobsen, Hayashi, Maulide and others are discussed.
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