Dissolving Microneedles Drug Delivery System: A Comprehensive Review

Dissolving microneedles (DMN) are tiny needles designed for painless drug delivery through the skin, offering effective treatment with minimal discomfort. This innovative transdermal delivery method has sparked interest in various fields such as oligonucleotide, vaccine, and insulin delivery. With applications in disease management, immunobiology, and cosmetics, DMNs show great potential in the biomedical field. Wearable devices incorporating DMN patches could revolutionize disease management by combining diagnosis and treatment. Microneedles enhance drug delivery by creating microchannels in the skin, evolving from simple solid needles to hollow, coated, dissolving, and hydrogel-forming varieties. These advancements have expanded the scope of drug delivery to include ocular, oral mucosal, gastrointestinal, ungual, and vaginal administration. Microneedle-assisted drug delivery is expected to become widely applicable across various tissues and organs in the near future.