“All‐in‐One” MnO2@PtAuRu Nanoreactor for Self‐Replenishing and Cascade Catalytic Therapy of Cancer

Abstract Limited by the insufficient catalytic substrates such as H 2 O 2 and O 2 in the tumor microenvironment (TME), the continual propelling of nanozymes catalysis therapy of cancer remains a challenge. Here, an all‐in‐one MnO 2 @PtAuRu nanoreactor is constructed for self‐propelled and cascade catalytic therapy of tumors. The MnO 2 @PtAuRu is constructed by using hollow MnO 2 (≈150 nm) as the core‐carrier and ultrasmall PtAuRu nanoclusters (≈2 nm) anchoring on the surface MnO 2 . According to the glucose oxidase (GOD)/catalase (CAT)/peroxidase (POD) mimic multienzyme activity of PtAuRu nanoclusters, cascaded nanocatalytic reactions can be self‐replenishing to persistently produce •OH for superior chemodynamic therapy (CDT). Additionally, the MnO 2 carrier can protect the ultrasmall PtAuRu nanoclusters during the circulation and the overexpressed glutathione (GSH) in the tumor can also be degraded by the MnO 2 to synergy the CDT. The MnO 2 @PtAuRu displays obvious photothermal properties which further enhance the cascade catalytic ability and synergistic therapeutic effect. Therefore, this all‐in‐one nanozyme provides a promising strategy for the rational design of self‐replenishment and self‐replenishing cascade catalytic therapy of cancer.