早熟
炎症
衰老
肿瘤坏死因子α
免疫系统
骨关节炎
生物
基因
医学
内科学
免疫学
病理
遗传学
替代医学
作者
Ping Guo,Xueqin Gao,Anna Laura Nelson,Matthieu Huard,Aiping Lu,William S. Hambright,Xueqin Gao
标识
DOI:10.1016/j.ymthe.2024.07.027
摘要
Osteoarthritis (OA) pain is often associated with the expression of tumor necrosis factor alpha (TNF-α), suggesting that TNF-α is one of the main contributing factors that cause inflammation, pain, and OA pathology. Thus, inhibition of TNF-α could potentially improve OA symptoms and slow disease progression. Anti-TNF-α treatments with antibodies, however, require multiple treatments and cannot entirely block TNF-α. TNF-α-induced protein 8-like 2 (TIPE2) was found to regulate the immune system's homeostasis and inflammation through different mechanisms from anti-TNF-α therapies. With a single treatment of adeno-associated virus (AAV)-TIPE2 gene delivery in the accelerated aging Zmpste24
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