亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Cognitive Motor Dissociation in Disorders of Consciousness

功能磁共振成像 离解(化学) 脑电图 意识障碍 意识 听力学 认知 最小意识状态 持续植物状态 心理学 神经影像学 彗差(光学) 静息状态功能磁共振成像 意识水平 医学 精神科 神经科学 发展心理学 化学 物理化学 物理 光学
作者
Yelena G. Bodien,Judith Allanson,Paolo Cardone,Arthur Bonhomme,Jerina Carmona,Camille Chatelle,Srivas Chennu,Mary M. Conte,Severine Dehaene,Paola Finoia,Gregory Heinonen,Jennifer Hersh,Evelyn Kamau,Phoebe Lawrence,Victoria Lupson,Anogue Meydan,Benjamin Rohaut,William R. Sanders,Jacobo Sitt,Andrea Soddu,Mélanie Valente,Ángela Velázquez,Henning U. Voss,Athina Vrosgou,Jan Claassen,Brian L. Edlow,Joseph J. Fins,Olivia Gosseries,Steven Laureys,David Menon,Lionel Naccache,Adrian M. Owen,John D. Pickard,Emmanuel A. Stamatakis,Aurore Thibaut,Jonathan D. Victor,Joseph T. Giacino,Emilia Bagiella,Nicholas D. Schiff
出处
期刊:The New England Journal of Medicine [New England Journal of Medicine]
卷期号:391 (7): 598-608 被引量:2
标识
DOI:10.1056/nejmoa2400645
摘要

BackgroundPatients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as cognitive motor dissociation, has not been systematically studied in a large cohort of persons with disorders of consciousness.MethodsIn this prospective cohort study conducted at six international centers, we collected clinical, behavioral, and task-based fMRI and EEG data from a convenience sample of 353 adults with disorders of consciousness. We assessed the response to commands on task-based fMRI or EEG in participants without an observable response to verbal commands (i.e., those with a behavioral diagnosis of coma, vegetative state, or minimally conscious state–minus) and in participants with an observable response to verbal commands. The presence or absence of an observable response to commands was assessed with the use of the Coma Recovery Scale–Revised (CRS-R).ResultsData from fMRI only or EEG only were available for 65% of the participants, and data from both fMRI and EEG were available for 35%. The median age of the participants was 37.9 years, the median time between brain injury and assessment with the CRS-R was 7.9 months (25% of the participants were assessed with the CRS-R within 28 days after injury), and brain trauma was an etiologic factor in 50%. We detected cognitive motor dissociation in 60 of the 241 participants (25%) without an observable response to commands, of whom 11 had been assessed with the use of fMRI only, 13 with the use of EEG only, and 36 with the use of both techniques. Cognitive motor dissociation was associated with younger age, longer time since injury, and brain trauma as an etiologic factor. In contrast, responses on task-based fMRI or EEG occurred in 43 of 112 participants (38%) with an observable response to verbal commands.ConclusionsApproximately one in four participants without an observable response to commands performed a cognitive task on fMRI or EEG as compared with one in three participants with an observable response to commands. (Funded by the James S. McDonnell Foundation and others.)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
机智的映之完成签到 ,获得积分10
5秒前
岳小龙完成签到 ,获得积分10
16秒前
ZYH发布了新的文献求助10
18秒前
炙热的夜雪完成签到 ,获得积分10
23秒前
明理丹烟应助zyh1117采纳,获得10
31秒前
37秒前
仔仔完成签到 ,获得积分10
51秒前
Cosima完成签到 ,获得积分10
57秒前
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
赘婿应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
1分钟前
1分钟前
所所应助xiaoliu采纳,获得10
2分钟前
2分钟前
所所应助王新月想毕业采纳,获得10
2分钟前
2分钟前
2分钟前
王新月想毕业完成签到,获得积分20
2分钟前
xiaoliu发布了新的文献求助10
2分钟前
2分钟前
Jasper应助Enma采纳,获得10
2分钟前
阿甲发布了新的文献求助10
2分钟前
zyh1117完成签到,获得积分10
2分钟前
zyh1117发布了新的文献求助10
2分钟前
冷静新烟发布了新的文献求助10
2分钟前
laihuimin完成签到,获得积分10
2分钟前
3分钟前
冷静新烟发布了新的文献求助10
3分钟前
rita_sun1969发布了新的文献求助20
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
爆米花应助科研通管家采纳,获得10
3分钟前
英姑应助ZYH采纳,获得10
3分钟前
李爱国应助冷静新烟采纳,获得10
3分钟前
3分钟前
ZYH发布了新的文献求助10
3分钟前
吃了一口还想吃完成签到,获得积分10
3分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052500
求助须知:如何正确求助?哪些是违规求助? 2709768
关于积分的说明 7418155
捐赠科研通 2354355
什么是DOI,文献DOI怎么找? 1245845
科研通“疑难数据库(出版商)”最低求助积分说明 605909
版权声明 595908