Palladium-Catalyzed Hydrophosphination of Terminal Alkynes with Diphenylphosphine Oxide in the Presence of Tetraphenyldiphosphine Monoxide

In this study, the Pd(OAc)2-catalyzed hydrophosphination of terminal alkynes was investigated in detail by using various diphosphines, which have a P–P bond, and the detailed mechanistic insights led to the successful development of a novel Pd-catalyzed hydrophosphination of terminal alkynes using Ph2P(O)H as both the phosphorus and hydrogen source. This catalytic transformation was successfully promoted in the presence of catalytic Ph2P(O)–PPh2, and the corresponding alkenylphosphine oxide was obtained in moderate to excellent yields with excellent product selectivity.