急性呼吸窘迫综合征
炎症
肺
抗生素
肺部感染
胆固醇
免疫学
微生物学
药理学
医学
化学
生物
生物化学
内科学
作者
Jin Gao,Yujie Su,Zhenjia Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2023-05-01
卷期号:296: 122071-122071
被引量:12
标识
DOI:10.1016/j.biomaterials.2023.122071
摘要
Lung bacterial infections could result in acute lung inflammation/injury (ALI) that propagates to its severe form, acute respiratory distress syndrome (ADRS) leading to the death. The molecular mechanism of ALI is associated with bacterial invasion and the host inflammation response. Here, we proposed a novel strategy to specifically target both bacteria and inflammatory pathways by co-loading of antibiotics (azlocillin, AZ) and anti-inflammatory agents (methylprednisolone sodium, MPS) in neutrophil nanovesicles. We found that cholesterol infilling in the membrane of nanovesicles can maintain a pH gradient between intra-vesicles and outer-vesicles, so we remotely loaded both AZ and MPS in single nanovesicles. The results showed that loading efficiency of both drugs can achieve more than 30% (w/w), and delivery of both drugs using nanovesicles accelerated bacterial clearance and resolved inflammation responses, thus preventing the potential lung damage due to infections. Our studies show that remote loading of multiple drugs in neutrophil nanovesicles which specifically target the infectious lung could be translational to treat ARDS.
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