直接荧光抗体
天疱疮
免疫荧光
病理
IIf公司
医学
海绵状
皮肤病科
大疱性类天疱疮
组织病理学
氨苯砜
疱疹样皮炎
叶状天疱疮
自身抗体
抗体
免疫学
疾病
作者
Rawat Kavita,Azad Sheenam,Bahal Neelima,Bisht S. Jitender
标识
DOI:10.4103/ijpm.ijpm_879_20
摘要
Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA deposits along basement zone. Indirect immunofluorescence (IIF) revealed antibodies to desmoglein1 (Dsg-1) positive. A final diagnosis of PH was given. The patient responded well to treatment with dapsone and steroids.
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