A new hypothesis for the mechanism of glyphosate induced intestinal permeability in the pathogenesis of polycystic ovary syndrome

Our understanding of the pathogenesis of polycystic ovary syndrome (PCOS) has been gradually evolving over many years. Studies suggest that there is a strong genetic component that is influenced by the gestational environment and subsequent lifestyle factors. The Dysbiosis of Gut Microbiota (DOGMA) theory has been proposed as a possible explanation of all the observed clinical and pathophysiological features of PCOS. This new paradigm suggests that poor quality diet results in disturbance of bowel bacterial flora causing mucosal damage and increased intestinal permeability. This initiates a cascade of events that results in the observed systemic features of PCOS. The human population is exposed to a large number of environmental toxins that result in a significant body burden of foreign chemicals. A number of these ubiquitous environmental chemicals have been identified as having a possible role in the pathogenesis of PCOS. The objective of the current study is to develop a new hypothesis for the possible role of the herbicide glyphosate in the existing pathogenic model.