Fabrication of gelatin- and collagen-based hydrogels for controlled drug release

Event Abstract Back to Event Fabrication of gelatin- and collagen-based hydrogels for controlled drug release Jiashing Yu1, Tzu-Chun Lai1 and Wer-Bor Tsai1 1 National Taiwan University, Chemical Engineering, Taiwan Gelatin and collagen possess excellent biocompatibility, biodegradability and bioactivity. However, their poor mechanical properties and fast degradation rates need to be overcome while they are used for biomedical applications. In this study, we fabricated gelatin- and collagen-based hydrogels for controlled drug release. To improve their physical properties, we tried to incorporate small molecules, carboxybetaine methacrylate (CBMA) and poly(ethylene glycol) diacrylate (PEGDA), into gelatin and collagen hydrogels, respectively. In the first part of study, gelatin methacrylate (GelMA) was firstly synthesized and then formed hydrogels together with CBMA to modulate the properties of gelatin-based hydrogels. With the incorporation of CBMA, better mechanical property, slower degradation rate and retarded drug release rate were observed. GelMA/CBMA hydrogels also showed good cell viability. As to the in vivo test, vascular endothelial growth factor (VEGF)-loaded GelMA/CBMA hydrogels displayed a certain degree of angiogenesis. In the second part of study, maleilated collagen (ColMA) was synthesized and incorporated with PEGDA to form ColMA/PEGDA hydrogels. DSC analysis indicated that ColMA still retained the triple helical structure. Although there was no significant improvement in mechanical properties of ColMA/PEGDA hydrogels, however, the introduction of PEGDA resulted in an enhanced crosslinking rate and a controlled release of fluorescein isothiocyanate-dextran (FITC-dextran) with higher molecular weight. Ministry of Science and Technology, R.O.C.References:[1] Buwalda, S.J., et al., Hydrogels in a historical perspective: from simple networks to smart materials. J Control Release, 2014. 190: p. 254-73.[2] Sutter, M., et al., Recombinant gelatin hydrogels for the sustained release of proteins. J Control Release, 2007. 119(3): p. 301-12. Keywords: Hydrogel, Drug delivery, polymer, biomacromolecule Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials for therapeutic delivery Citation: Yu J, Lai T and Tsai W (2016). Fabrication of gelatin- and collagen-based hydrogels for controlled drug release. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00321 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers' terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jiashing Yu Tzu-Chun Lai Wer-Bor Tsai Google Jiashing Yu Tzu-Chun Lai Wer-Bor Tsai Google Scholar Jiashing Yu Tzu-Chun Lai Wer-Bor Tsai PubMed Jiashing Yu Tzu-Chun Lai Wer-Bor Tsai Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.