Visible Spectophotometric Methods For Estimation Of Clarithromycin From Tablet Formulation

Three simple visible spectropbotometric methods have been developed for the estimation of clarithromycin from tablet formulation. The first developed method is based on formation of orange-red coloured complex of drug with concentrated hydrochloric acid and acetone. The coloured complex shows absorbance maxima at 485 nm and obeys Beer's law in concentration range of 50-500 I¼g/ml. Second and third developed methods are based on formation of chloroform extractable complex of drug with bromocresol green and bromopbenol blue, respectively, both of which show abaorixince maxima at 414 nm and linearity in concentration range of 0-60 I¼g/ml of drug. Results of analysis for all the methods were validated statistically and by recoveiy studies.