化学
丙二酸
布洛芬
产量(工程)
苯巴比妥
有机化学
药物化学
药理学
医学
材料科学
冶金
作者
John T. Pinhey,B. A. ROWE
标识
DOI:10.1016/s0040-4039(00)77752-5
摘要
Derivatives of Meldrum's acid and the sodium salts of substituted malonic esters undergo rapid arylation in high yield when treated with aryllead triacetates. These reactions have been applied to the synthesis of ibuprofen, an analgesic, and in a closely related reaction 5-ethylbarbituric acid has been reacted with phenyllead triacetate to give phenobarbital.
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